King's College London

Research portal

Cardiac troponin and defining myocardial infarction

Research output: Contribution to journalReview articlepeer-review

Original languageEnglish
Pages (from-to)2203-2215
Number of pages13
JournalCardiovascular Research
Issue number10
Early online date17 Jan 2021
Accepted/In press1 Oct 2020
E-pub ahead of print17 Jan 2021
Published1 Sep 2021

Bibliographical note

Funding Information: This work was supported by grants from the Medical Research Council (London, UK) (G1000737), Guy's and St Thomas' Charity (London, UK; R060701, R100404), British Heart Foundation (Birmingham, London; TG/15/ 1/31518, FS/15/13/31320), and the UK Department of Health through the National Institute for Health Research Biomedical Research Centre award to Guy's & St Thomas' National Health Service Foundation Trust. Dr Kaier is funded through an National Institute for Health Research clinical lectureship (CL-2019-17-006). Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

King's Authors


The 4th Universal Definition of Myocardial Infarction has stimulated considerable debate since its publication in 2018. The intention was to define the types of myocardial injury through the lens of their underpinning pathophysiology. In this review, we discuss how the 4th Universal Definition of Myocardial Infarction defines infarction and injury and the necessary pragmatic adjustments that appear in clinical guidelines to maximize triage of real-world patients.

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454