Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16 weeks--an MRI study

Carolyn A Carr, Daniel J Stuckey, Jun Jie Tan, Suat Cheng Tan, Renata S M Gomes, Patrizia Camelliti, Elisa Messina, Alessandro Giacomello, Georgina M Ellison, Kieran Clarke

    Research output: Contribution to journalArticlepeer-review

    66 Citations (Scopus)

    Abstract

    Endogenous cardiac progenitor cells, expanded from explants via cardiosphere formation, present a promising cell source to prevent heart failure following myocardial infarction. Here we used cine-magnetic resonance imaging (MRI) to track administered cardiosphere-derived cells (CDCs) and to measure changes in cardiac function over four months in the infarcted rat heart.
    Original languageEnglish
    Article numbere25669
    JournalPLoS ONE
    Volume6
    Issue number10
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Animals
    • Ferric Compounds
    • Green Fluorescent Proteins
    • Cell Differentiation
    • Myoblasts, Cardiac
    • Heart Function Tests
    • Rats
    • Animals, Newborn
    • Magnetic Resonance Imaging, Cine
    • Treatment Outcome
    • Myocardial Infarction
    • Stem Cell Transplantation
    • Time Factors

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