King's College London

Research portal

Cardiovascular risk factors and metabolic syndrome in people with established psychotic illnesses: baseline data from the IMPaCT randomized controlled trial

Research output: Contribution to journalArticle

P. Gardner-Sood, J. Lally, S. Smith, Z. Atakan, K. Ismail, K. E. Greenwood, A. Keen, C. O'Brien, O. Onagbesan, C Fung, E. Papanastasiou, J. Eberhard, A. Patel, R. Ohlsen, D. Stahl, A. David, D. Hopkins, R. M. Murray, F. Gaughran, on behalf of the IMPaCT Team

Original languageEnglish
Pages (from-to)2619-2629
Number of pages11
JournalPsychological Medicine
Volume45
Issue number12
Early online date12 May 2015
DOIs
Publication statusPublished - 5 Sep 2015

Documents

King's Authors

Abstract

Background

The aims of the study were to determine the prevalence of cardiometabolic risk factors and establish the proportion of people with psychosis meeting criteria for the metabolic syndrome (MetS). The study also aimed to identify the key lifestyle behaviours associated with increased risk of the MetS and to investigate whether the MetS is associated with illness severity and degree of functional impairment.


Method

Baseline data were collected as part of a large randomized controlled trial (IMPaCT RCT). The study took place within community mental health teams in five Mental Health NHS Trusts in urban and rural locations across England. A total of 450 randomly selected out-patients, aged 18–65 years, with an established psychotic illness were recruited. We ascertained the prevalence rates of cardiometabolic risk factors, illness severity and functional impairment and calculated rates of the MetS, using International Diabetes Federation (IDF) and National Cholesterol Education Program Third Adult Treatment Panel criteria.


Results

High rates of cardiometabolic risk factors were found. Nearly all women and most men had waist circumference exceeding the IDF threshold for central obesity. Half the sample was obese (body mass index ≥ 30 kg/m2) and a fifth met the criteria for type 2 diabetes mellitus. Females were more likely to be obese than males (61% v. 42%, p < 0.001). Of the 308 patients with complete laboratory measures, 57% (n = 175) met the IDF criteria for the MetS.


Conclusions

In the UK, the prevalence of cardiometabolic risk factors in individuals with psychotic illnesses is much higher than that observed in national general population studies as well as in most international studies of patients with psychosis.


Corrigendum Cardiovascular risk factors and metabolic syndrome in people withestablished psychotic illnesses: baseline data from the IMPaCT RCTstudy-Corrigendum.
P. Gardner-Sood, J. Lally, S. Smith, Z. Atakan, K. Ismail, K. E. Greenwood, A. Keen, C. O’Brien,O. Onagbesan, C. Fung, E. Papanastasiou, J. Eberherd, A. Patel, R. Ohlsen, D. Stahl, A. David,D. Hopkins, R. M. Murray and F. Gaughran on behalf of the IMPaCT team. doi: 10.1017/S0033291715000562. Published online by Cambridge University Press, 12 May 2015. 
The author regrets to announce that affiliation 8, in the above article (Gardner-Sood et al. 2015), contained an errorin the author affiliation address and author surname, which were published in the approved article. The correctsurname and affiliation address are given below. 
J. Eberharda3a88 Clinical Psychiatric Research Center, Lund University, Skåne, Sweden 
Reference 
P. Gardner-Sood, J. Lally, S. Smith, Z. Atakan, K. Ismail, K. E. Greenwood, A. Keen, C. O’Brien, O. Onagbesan,C. Fung, E. Papanastasiou, J. Eberherd, A. Patel, R. Ohlsen, D. Stahl, A. David, D. Hopkins, R. M. Murray,F. Gaughran and on behalf of the IMPaCT team (2015). Cardiovascular risk factors and metabolic syndrome inpeople with established psychotic illnesses: baseline data from the IMPaCT RCT study-Corrigendum.Psychological Medicine doi: 10.1017/S0033291715000562.

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454