Cariprazine as a treatment for negative psychotic symptoms in first-episode psychosis: Case series

Arsime Demjaha*, Eduardo Iacoponi, Lars Hansen, Pradeep Peddu, Philip McGuire

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)
44 Downloads (Pure)

Abstract

Negative psychotic symptoms are among the most disabling features of schizophrenia, and are strongly associated with relatively poor clinical and functional outcomes. However, there are no effective treatments for negative symptoms, and this represents a major unmet clinical need. Recent research has shown that negative symptoms are already present in many patients at illness onset. There is evidence that cariprazine may improve negative symptoms in patients with chronic schizophrenia. However, its utility in treating negative symptoms in the early stage of the disorder is unclear. Here, we report six cases of patients with first-episode psychosis who were treated with cariprazine.

Original languageEnglish
Article numbere88
JournalBJPsych Open
Volume8
Issue number3
DOIs
Publication statusPublished - 28 May 2022

Keywords

  • Antipsychotics
  • Cariprazine
  • First-episode psychosis
  • Negative symptoms
  • Novel central nervous system drugs

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