Caspase-7 participates in differentiation of cells forming dental hard tissues

Eva Matalova*, Herve Lesot, Eva Svandova, Tom Vanden Berghe, Paul T. Sharpe, Christopher Healy, Peter Vandenabeele, Abigail S. Tucker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

Apoptosis during tooth development appears dependent on the apoptotic executioner caspase-3, but not caspase-7. Instead, activated caspase-7 has been found in differentiated odontoblasts and ameloblasts, where it does not correlate with apoptosis. To further investigate these findings, the mouse incisor was used as a model. Analysis of caspase-7-deficient mice revealed a significant thinner layer of hard tissue in the adult incisor. Micro computed tomography scan confirmed this decrease in mineralized tissues. These data strongly suggest that caspase-7 might be directly involved in functional cell differentiation and regulation of the mineralization of dental matrices.

Original languageEnglish
Pages (from-to)615-621
Number of pages7
JournalDEVELOPMENT GROWTH AND DIFFERENTIATION
Volume55
Issue number5
DOIs
Publication statusPublished - Jun 2013

Keywords

  • ameloblast
  • apoptosis
  • caspase
  • cell differentiation
  • odontoblast
  • MOLAR TOOTH DEVELOPMENT
  • STEM-CELLS
  • DEFICIENT MICE
  • FACTORS FAS
  • APOPTOSIS
  • EXPRESSION
  • MESENCHYME
  • DENTITION
  • PROTEINS
  • SURVIVAL

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