Ca2+ handling and sensitivity in airway smooth muscle: Emerging concepts for mechanistic understanding and therapeutic targeting

T. Koopmans; V. Anaparti; I. Castro-Piedras; P. Yarova; N. Irechukwu; C. Nelson; J. Perez-Zoghbi; X. Tan; J. P T Ward; D. B. Wright

doi:10.1016/j.pupt.2014.05.001

Ca²⁺ handling and sensitivity in airway smooth muscle: Emerging concepts for mechanistic understanding and therapeutic targeting

T. Koopmans, V. Anaparti, I. Castro-Piedras, P. Yarova, N. Irechukwu, C. Nelson, J. Perez-Zoghbi, X. Tan, J. P T Ward, D. B. Wright^*

^*Corresponding author for this work

King's College London

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Free calcium ions within the cytosol serve as a key secondary messenger system for a diverse range of cellular processes. Dysregulation of cytosolic Ca²⁺ handling in airway smooth muscle (ASM) has been implicated in asthma, and it has been hypothesised that this leads, at least in part, to associated changes in both the architecture and function of the lung. Significant research is therefore directed towards furthering our understanding of the mechanisms which control ASM cytosolic calcium, in addition to those regulating the sensitivity of its downstream effector targets to calcium. Key aspects of the recent developments in this field were discussed at the 8th Young Investigators' Symposium on Smooth Muscle (2013, Groningen, The Netherlands), and are outlined in this review.

Original language	English
Pages (from-to)	108-120
Number of pages	13
Journal	Pulmonary pharmacology & therapeutics
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.pupt.2014.05.001
Publication status	Published - 2014

Keywords

Airway smooth muscle
Asthma
Calcium
Contraction
Sensitisation
WNT

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.pupt.2014.05.001

Cite this

Koopmans, T., Anaparti, V., Castro-Piedras, I., Yarova, P., Irechukwu, N., Nelson, C., Perez-Zoghbi, J., Tan, X., Ward, J. P. T., & Wright, D. B. (2014). Ca²⁺ handling and sensitivity in airway smooth muscle: Emerging concepts for mechanistic understanding and therapeutic targeting. Pulmonary pharmacology & therapeutics, 29(2), 108-120. https://doi.org/10.1016/j.pupt.2014.05.001

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abstract = "Free calcium ions within the cytosol serve as a key secondary messenger system for a diverse range of cellular processes. Dysregulation of cytosolic Ca2+ handling in airway smooth muscle (ASM) has been implicated in asthma, and it has been hypothesised that this leads, at least in part, to associated changes in both the architecture and function of the lung. Significant research is therefore directed towards furthering our understanding of the mechanisms which control ASM cytosolic calcium, in addition to those regulating the sensitivity of its downstream effector targets to calcium. Key aspects of the recent developments in this field were discussed at the 8th Young Investigators' Symposium on Smooth Muscle (2013, Groningen, The Netherlands), and are outlined in this review.",

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Koopmans, T, Anaparti, V, Castro-Piedras, I, Yarova, P, Irechukwu, N, Nelson, C, Perez-Zoghbi, J, Tan, X, Ward, JPT & Wright, DB 2014, 'Ca²⁺ handling and sensitivity in airway smooth muscle: Emerging concepts for mechanistic understanding and therapeutic targeting', Pulmonary pharmacology & therapeutics, vol. 29, no. 2, pp. 108-120. https://doi.org/10.1016/j.pupt.2014.05.001

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T2 - Emerging concepts for mechanistic understanding and therapeutic targeting

AU - Koopmans, T.

AU - Anaparti, V.

AU - Castro-Piedras, I.

AU - Yarova, P.

AU - Irechukwu, N.

AU - Nelson, C.

AU - Perez-Zoghbi, J.

AU - Tan, X.

AU - Ward, J. P T

AU - Wright, D. B.

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AB - Free calcium ions within the cytosol serve as a key secondary messenger system for a diverse range of cellular processes. Dysregulation of cytosolic Ca2+ handling in airway smooth muscle (ASM) has been implicated in asthma, and it has been hypothesised that this leads, at least in part, to associated changes in both the architecture and function of the lung. Significant research is therefore directed towards furthering our understanding of the mechanisms which control ASM cytosolic calcium, in addition to those regulating the sensitivity of its downstream effector targets to calcium. Key aspects of the recent developments in this field were discussed at the 8th Young Investigators' Symposium on Smooth Muscle (2013, Groningen, The Netherlands), and are outlined in this review.

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KW - Sensitisation

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