Catalytic meta-selective C-H functionalization to construct quaternary carbon centres

Andrew J. Paterson; Sahra St John-Campbell; Mary F. Mahon; Neil J. Press; Christopher G. Frost

doi:10.1039/c5cc03951g

Catalytic meta-selective C-H functionalization to construct quaternary carbon centres

Andrew J. Paterson, Sahra St John-Campbell, Mary F. Mahon, Neil J. Press, Christopher G. Frost^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

142 Citations (Scopus)

Abstract

A catalytic meta-selective C-H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C-H functionalization proceeds through a radical process directed via a remote σ-activation.

Original language	English
Pages (from-to)	12807-12810
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	64
DOIs	https://doi.org/10.1039/c5cc03951g
Publication status	Published - 18 Aug 2015

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abstract = "A catalytic meta-selective C-H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C-H functionalization proceeds through a radical process directed via a remote σ-activation.",

author = "Paterson, {Andrew J.} and {St John-Campbell}, Sahra and Mahon, {Mary F.} and Press, {Neil J.} and Frost, {Christopher G.}",

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AU - Paterson, Andrew J.

AU - St John-Campbell, Sahra

AU - Mahon, Mary F.

AU - Press, Neil J.

AU - Frost, Christopher G.

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2015/8/18

Y1 - 2015/8/18

N2 - A catalytic meta-selective C-H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C-H functionalization proceeds through a radical process directed via a remote σ-activation.

AB - A catalytic meta-selective C-H functionalization of 2-phenylpyridines using a range of tertiary halides is described. The protocol is simple to perform and uses commercially available reagents to construct challenging quaternary carbon centres in a regioselective manner. Preliminary studies suggest the C-H functionalization proceeds through a radical process directed via a remote σ-activation.

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U2 - 10.1039/c5cc03951g

DO - 10.1039/c5cc03951g

M3 - Article

C2 - 26166441

AN - SCOPUS:84938278454

SN - 1359-7345

VL - 51

SP - 12807

EP - 12810

JO - Chemical Communications

JF - Chemical Communications

IS - 64

ER -

Catalytic meta-selective C-H functionalization to construct quaternary carbon centres

Abstract

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