Catatonic features in children and adolescents with N-methyl- d -aspartate receptor antibody encephalitis

Michael Eyre; Anya Kaushik; Elizabeth Barrett; Mary D. King; Thomas Pollak; Russell C. Dale; Susan Byrne; Ming Lim

doi:10.1192/bjo.2020.55

Catatonic features in children and adolescents with N-methyl- d -aspartate receptor antibody encephalitis

Michael Eyre, Anya Kaushik, Elizabeth Barrett, Mary D. King, Thomas Pollak, Russell C. Dale, Susan Byrne, Ming Lim

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Catatonia is a psychomotor dysregulation syndrome of diverse aetiology, increasingly recognised as a prominent feature of N-methyl-d-aspartate receptor antibody encephalitis (NMDARE) in adults. No study to date has systematically assessed the prevalence and symptomatology of catatonia in children with NMDARE. We analysed 57 paediatric patients with NMDARE from the literature using the Bush-Francis Catatonia Rating Scale. Catatonia was common (occurring in 86% of patients), manifesting as complex clusters of positive and negative features within individual patients. It was both underrecognised and undertreated. Immunotherapy was the only effective intervention, highlighting the importance of prompt recognition and treatment of the underlying cause of catatonia.

Original language	English
Article number	e71
Journal	BJPsych Open
Volume	6
Issue number	4
DOIs	https://doi.org/10.1192/bjo.2020.55
Publication status	Published - 2020

Keywords

Clinical neurology
drug interactions and side effects
inpatient treatment
neuroimmunology
organic syndromes

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title = "Catatonic features in children and adolescents with N-methyl- d -aspartate receptor antibody encephalitis",

abstract = "Catatonia is a psychomotor dysregulation syndrome of diverse aetiology, increasingly recognised as a prominent feature of N-methyl-d-aspartate receptor antibody encephalitis (NMDARE) in adults. No study to date has systematically assessed the prevalence and symptomatology of catatonia in children with NMDARE. We analysed 57 paediatric patients with NMDARE from the literature using the Bush-Francis Catatonia Rating Scale. Catatonia was common (occurring in 86% of patients), manifesting as complex clusters of positive and negative features within individual patients. It was both underrecognised and undertreated. Immunotherapy was the only effective intervention, highlighting the importance of prompt recognition and treatment of the underlying cause of catatonia. ",

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AU - Eyre, Michael

AU - Kaushik, Anya

AU - Barrett, Elizabeth

AU - King, Mary D.

AU - Pollak, Thomas

AU - Dale, Russell C.

AU - Byrne, Susan

AU - Lim, Ming

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Catatonic features in children and adolescents with N-methyl- d -aspartate receptor antibody encephalitis

Abstract

Keywords

UN SDGs

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