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Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies

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Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders : Data From a New Biobank and Meta-Analysis of Previously Published Studies. / Collantoni, Enrico; Solmi, Marco; Gallicchio, Davide; Santonastaso, Paolo; Meneguzzo, Paolo; Carvalho, Andrè F; Stubbs, Brendon; Clementi, Maurizio; Pinato, Claudia; Forzan, Monica; Cassina, Matteo; Fontana, Francesca; Piva, Ivana; Siani, Roberta; Salvo, Pierandrea; Tenconi, Elena; Veronese, Nicola; Correll, Christoph U; Favaro, Angela.

In: European eating disorders review : the journal of the Eating Disorders Association, Vol. 25, No. 6, 11.2017, p. 524-532.

Research output: Contribution to journalArticle

Harvard

Collantoni, E, Solmi, M, Gallicchio, D, Santonastaso, P, Meneguzzo, P, Carvalho, AF, Stubbs, B, Clementi, M, Pinato, C, Forzan, M, Cassina, M, Fontana, F, Piva, I, Siani, R, Salvo, P, Tenconi, E, Veronese, N, Correll, CU & Favaro, A 2017, 'Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies', European eating disorders review : the journal of the Eating Disorders Association, vol. 25, no. 6, pp. 524-532. https://doi.org/10.1002/erv.2555

APA

Collantoni, E., Solmi, M., Gallicchio, D., Santonastaso, P., Meneguzzo, P., Carvalho, A. F., ... Favaro, A. (2017). Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies. European eating disorders review : the journal of the Eating Disorders Association, 25(6), 524-532. https://doi.org/10.1002/erv.2555

Vancouver

Collantoni E, Solmi M, Gallicchio D, Santonastaso P, Meneguzzo P, Carvalho AF et al. Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies. European eating disorders review : the journal of the Eating Disorders Association. 2017 Nov;25(6):524-532. https://doi.org/10.1002/erv.2555

Author

Collantoni, Enrico ; Solmi, Marco ; Gallicchio, Davide ; Santonastaso, Paolo ; Meneguzzo, Paolo ; Carvalho, Andrè F ; Stubbs, Brendon ; Clementi, Maurizio ; Pinato, Claudia ; Forzan, Monica ; Cassina, Matteo ; Fontana, Francesca ; Piva, Ivana ; Siani, Roberta ; Salvo, Pierandrea ; Tenconi, Elena ; Veronese, Nicola ; Correll, Christoph U ; Favaro, Angela. / Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders : Data From a New Biobank and Meta-Analysis of Previously Published Studies. In: European eating disorders review : the journal of the Eating Disorders Association. 2017 ; Vol. 25, No. 6. pp. 524-532.

Bibtex Download

@article{60e482ccf5734266bd9454310ede40ee,
title = "Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders: Data From a New Biobank and Meta-Analysis of Previously Published Studies",
abstract = "OBJECTIVES: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs).METHODS: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian 'Biobanca Veneta per i Disturbi Alimentari' biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls.RESULTS: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96-1.04, p-values: 0.46-0.97, I(2)  = 0{\%}] and when analysing separately patients with AN (ORs: 0.94-1.04, p-values: 0.31-0.61, I(2)  = 0{\%}) or BN (ORs: 0.80-1.09, p-values: 0.28-0.64, I(2)  = 0-44{\%}).CONCLUSIONS: Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright {\circledC} 2017 John Wiley & Sons, Ltd and Eating Disorders Association.",
keywords = "Journal Article",
author = "Enrico Collantoni and Marco Solmi and Davide Gallicchio and Paolo Santonastaso and Paolo Meneguzzo and Carvalho, {Andr{\`e} F} and Brendon Stubbs and Maurizio Clementi and Claudia Pinato and Monica Forzan and Matteo Cassina and Francesca Fontana and Ivana Piva and Roberta Siani and Pierandrea Salvo and Elena Tenconi and Nicola Veronese and Correll, {Christoph U} and Angela Favaro",
note = "Copyright {\circledC} 2017 John Wiley & Sons, Ltd and Eating Disorders Association.",
year = "2017",
month = "11",
doi = "10.1002/erv.2555",
language = "English",
volume = "25",
pages = "524--532",
journal = "European eating disorders review : the journal of the Eating Disorders Association",
issn = "1072-4133",
number = "6",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Eating Disorders

T2 - Data From a New Biobank and Meta-Analysis of Previously Published Studies

AU - Collantoni, Enrico

AU - Solmi, Marco

AU - Gallicchio, Davide

AU - Santonastaso, Paolo

AU - Meneguzzo, Paolo

AU - Carvalho, Andrè F

AU - Stubbs, Brendon

AU - Clementi, Maurizio

AU - Pinato, Claudia

AU - Forzan, Monica

AU - Cassina, Matteo

AU - Fontana, Francesca

AU - Piva, Ivana

AU - Siani, Roberta

AU - Salvo, Pierandrea

AU - Tenconi, Elena

AU - Veronese, Nicola

AU - Correll, Christoph U

AU - Favaro, Angela

N1 - Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

PY - 2017/11

Y1 - 2017/11

N2 - OBJECTIVES: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs).METHODS: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian 'Biobanca Veneta per i Disturbi Alimentari' biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls.RESULTS: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96-1.04, p-values: 0.46-0.97, I(2)  = 0%] and when analysing separately patients with AN (ORs: 0.94-1.04, p-values: 0.31-0.61, I(2)  = 0%) or BN (ORs: 0.80-1.09, p-values: 0.28-0.64, I(2)  = 0-44%).CONCLUSIONS: Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

AB - OBJECTIVES: We investigated whether catechol-O-methyltransferase (COMT) Val158Met polymorphism is associated with eating disorders (EDs).METHODS: We conducted a systematic literature search of studies published until 15 January 2017 and added data from the Italian 'Biobanca Veneta per i Disturbi Alimentari' biobank, performing a meta-analysis comparing COMT Val158Met genotype and allele frequencies in EDs and anorexia nervosa (AN) or bulimia nervosa (BN) patients versus controls.RESULTS: Ten studies plus Biobanca Veneta per i Disturbi Alimentari (ED: n = 920, controls: n = 261 controls) with 3541 ED patients (AN = 2388; BN = 233) and 3684 controls were included. There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96-1.04, p-values: 0.46-0.97, I(2)  = 0%] and when analysing separately patients with AN (ORs: 0.94-1.04, p-values: 0.31-0.61, I(2)  = 0%) or BN (ORs: 0.80-1.09, p-values: 0.28-0.64, I(2)  = 0-44%).CONCLUSIONS: Meta-analysing data results from 11 studies and 7225 subjects show that COMT Val158Met polymorphism is not associated with EDs. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.

KW - Journal Article

U2 - 10.1002/erv.2555

DO - 10.1002/erv.2555

M3 - Article

C2 - 29057600

VL - 25

SP - 524

EP - 532

JO - European eating disorders review : the journal of the Eating Disorders Association

JF - European eating disorders review : the journal of the Eating Disorders Association

SN - 1072-4133

IS - 6

ER -

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