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Cause of death among HIV patients in London in 2016

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Cause of death among HIV patients in London in 2016. / Croxford, S.; Miller, R. F.; Post, F. A.; Harding, R.; Lucas, S. B.; Figueroa, J.; Harrison, I.; Delpech, V. C.; Dhoot, S.; Sullivan, A. K.

In: HIV MEDICINE, Vol. 20, No. 9, 01.10.2019, p. 628-633.

Research output: Contribution to journalArticle

Harvard

Croxford, S, Miller, RF, Post, FA, Harding, R, Lucas, SB, Figueroa, J, Harrison, I, Delpech, VC, Dhoot, S & Sullivan, AK 2019, 'Cause of death among HIV patients in London in 2016', HIV MEDICINE, vol. 20, no. 9, pp. 628-633. https://doi.org/10.1111/hiv.12761

APA

Croxford, S., Miller, R. F., Post, F. A., Harding, R., Lucas, S. B., Figueroa, J., Harrison, I., Delpech, V. C., Dhoot, S., & Sullivan, A. K. (2019). Cause of death among HIV patients in London in 2016. HIV MEDICINE, 20(9), 628-633. https://doi.org/10.1111/hiv.12761

Vancouver

Croxford S, Miller RF, Post FA, Harding R, Lucas SB, Figueroa J et al. Cause of death among HIV patients in London in 2016. HIV MEDICINE. 2019 Oct 1;20(9):628-633. https://doi.org/10.1111/hiv.12761

Author

Croxford, S. ; Miller, R. F. ; Post, F. A. ; Harding, R. ; Lucas, S. B. ; Figueroa, J. ; Harrison, I. ; Delpech, V. C. ; Dhoot, S. ; Sullivan, A. K. / Cause of death among HIV patients in London in 2016. In: HIV MEDICINE. 2019 ; Vol. 20, No. 9. pp. 628-633.

Bibtex Download

@article{5565de1fe93247b4a99747262370eb84,
title = "Cause of death among HIV patients in London in 2016",
abstract = "Objectives: Since 2013, the London HIV Mortality Review Group has conducted annual reviews of deaths among people with HIV to reduce avoidable mortality. Methods: All London HIV care Trusts reported data on 2016 patient deaths in 2017. Deaths were submitted using a modified Causes of Death in HIV reporting form and categorized by a specialist HIV pathologist and two HIV clinicians. Results: There were 206 deaths reported; 77% were among men. Median age at death was 56 years. Cause was established for 82% of deaths, with non-AIDS-related malignancies and AIDS-defining illnesses being the most common causes reported. Risk factors in the year before death included: tobacco smoking (37%), excessive alcohol consumption (19%), non-injecting drug use (10%), injecting drug use (7%) and opioid substitution therapy (6%). Thirty-nine per cent of patients had a history of depression, 33% chronic hypertension, 27% dyslipidaemia, 17% coinfection with hepatitis B virus and/or hepatitis C virus and 14% diabetes mellitus. At the time of death, 81% of patients were on antiretroviral therapy (ART), 61% had a CD4 count < 350 cells/μL, and 24% had a viral load ≥ 200 HIV-1 RNA copies/mL. Thirty-six per cent of deaths were unexpected; 61% of expected deaths were in hospital. Two-thirds of expected deaths had a prior end-of-life care discussion documented. Conclusions: In 2016, most deaths were attributable to non-AIDS-related conditions and the majority of patients were on ART and virally suppressed. However, several potentially preventable deaths were identified and underlying risk factors were common. As London HIV patients are not representative of people with HIV in the UK, a national mortality review is warranted.",
keywords = "cause of death, HIV, London, mortality",
author = "S. Croxford and Miller, {R. F.} and Post, {F. A.} and R. Harding and Lucas, {S. B.} and J. Figueroa and I. Harrison and Delpech, {V. C.} and S. Dhoot and Sullivan, {A. K.}",
year = "2019",
month = oct,
day = "1",
doi = "10.1111/hiv.12761",
language = "English",
volume = "20",
pages = "628--633",
journal = "HIV MEDICINE",
issn = "1464-2662",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Cause of death among HIV patients in London in 2016

AU - Croxford, S.

AU - Miller, R. F.

AU - Post, F. A.

AU - Harding, R.

AU - Lucas, S. B.

AU - Figueroa, J.

AU - Harrison, I.

AU - Delpech, V. C.

AU - Dhoot, S.

AU - Sullivan, A. K.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Objectives: Since 2013, the London HIV Mortality Review Group has conducted annual reviews of deaths among people with HIV to reduce avoidable mortality. Methods: All London HIV care Trusts reported data on 2016 patient deaths in 2017. Deaths were submitted using a modified Causes of Death in HIV reporting form and categorized by a specialist HIV pathologist and two HIV clinicians. Results: There were 206 deaths reported; 77% were among men. Median age at death was 56 years. Cause was established for 82% of deaths, with non-AIDS-related malignancies and AIDS-defining illnesses being the most common causes reported. Risk factors in the year before death included: tobacco smoking (37%), excessive alcohol consumption (19%), non-injecting drug use (10%), injecting drug use (7%) and opioid substitution therapy (6%). Thirty-nine per cent of patients had a history of depression, 33% chronic hypertension, 27% dyslipidaemia, 17% coinfection with hepatitis B virus and/or hepatitis C virus and 14% diabetes mellitus. At the time of death, 81% of patients were on antiretroviral therapy (ART), 61% had a CD4 count < 350 cells/μL, and 24% had a viral load ≥ 200 HIV-1 RNA copies/mL. Thirty-six per cent of deaths were unexpected; 61% of expected deaths were in hospital. Two-thirds of expected deaths had a prior end-of-life care discussion documented. Conclusions: In 2016, most deaths were attributable to non-AIDS-related conditions and the majority of patients were on ART and virally suppressed. However, several potentially preventable deaths were identified and underlying risk factors were common. As London HIV patients are not representative of people with HIV in the UK, a national mortality review is warranted.

AB - Objectives: Since 2013, the London HIV Mortality Review Group has conducted annual reviews of deaths among people with HIV to reduce avoidable mortality. Methods: All London HIV care Trusts reported data on 2016 patient deaths in 2017. Deaths were submitted using a modified Causes of Death in HIV reporting form and categorized by a specialist HIV pathologist and two HIV clinicians. Results: There were 206 deaths reported; 77% were among men. Median age at death was 56 years. Cause was established for 82% of deaths, with non-AIDS-related malignancies and AIDS-defining illnesses being the most common causes reported. Risk factors in the year before death included: tobacco smoking (37%), excessive alcohol consumption (19%), non-injecting drug use (10%), injecting drug use (7%) and opioid substitution therapy (6%). Thirty-nine per cent of patients had a history of depression, 33% chronic hypertension, 27% dyslipidaemia, 17% coinfection with hepatitis B virus and/or hepatitis C virus and 14% diabetes mellitus. At the time of death, 81% of patients were on antiretroviral therapy (ART), 61% had a CD4 count < 350 cells/μL, and 24% had a viral load ≥ 200 HIV-1 RNA copies/mL. Thirty-six per cent of deaths were unexpected; 61% of expected deaths were in hospital. Two-thirds of expected deaths had a prior end-of-life care discussion documented. Conclusions: In 2016, most deaths were attributable to non-AIDS-related conditions and the majority of patients were on ART and virally suppressed. However, several potentially preventable deaths were identified and underlying risk factors were common. As London HIV patients are not representative of people with HIV in the UK, a national mortality review is warranted.

KW - cause of death

KW - HIV

KW - London

KW - mortality

UR - http://www.scopus.com/inward/record.url?scp=85068615661&partnerID=8YFLogxK

U2 - 10.1111/hiv.12761

DO - 10.1111/hiv.12761

M3 - Article

AN - SCOPUS:85068615661

VL - 20

SP - 628

EP - 633

JO - HIV MEDICINE

JF - HIV MEDICINE

SN - 1464-2662

IS - 9

ER -

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