CC chemokine receptor 4 (CCR4) in human allergen-induced late nasal responses

G Banfield, H Watanabe, G Scadding, M R Jacobson, S J Till, D A Hall, D S Robinson, C M Lloyd, K T Nouri-Aria, S R Durham

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)


CC Chemokine receptor 4 (CCR4) is preferentially expressed on Th2 lymphocytes. CCR4-mediated inflammation may be important in the pathology of allergic rhinitis. Disruption of CCR4 - ligand interaction may abrogate allergen-induced inflammation.
Original languageEnglish
Pages (from-to)1126-33
Number of pages8
Issue number9
Publication statusPublished - Sept 2010


  • Humans
  • Biopsy
  • Th2 Cells
  • Receptors, CCR4
  • Inflammation
  • Rhinitis, Allergic, Perennial
  • Administration, Intranasal
  • Allergens
  • Rhinitis, Allergic, Seasonal
  • Adult
  • Hypersensitivity, Immediate
  • Nasal Mucosa
  • Time Factors
  • Female
  • Male


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