CCR4 in human allergen-induced late responses in the skin and lung

Kayhan T Nouri-Aria; Duncan Wilson; James N Francis; Louise A Jopling; Mikila R Jacobson; Martin R Hodge; David P Andrew; Stephen J Till; Eva-Maria Varga; Timothy J Williams; James E Pease; Clare M Lloyd; Ian Sabroe; Stephen R Durham

doi:10.1002/1521-4141(200207)32:7<1933::AID-IMMU1933>3.0.CO;2-R

CCR4 in human allergen-induced late responses in the skin and lung

Kayhan T Nouri-Aria, Duncan Wilson, James N Francis, Louise A Jopling, Mikila R Jacobson, Martin R Hodge, David P Andrew, Stephen J Till, Eva-Maria Varga, Timothy J Williams, James E Pease, Clare M Lloyd, Ian Sabroe, Stephen R Durham

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Abstract

We studied the regulation of CCR4 expression in peripheral blood and in human models of cutaneous and pulmonary allergen challenge. CCR4 expression was detectable on freshly isolated CD4+ lymphocytes and in CD4+ and CD8+ T cell lines derived from blood of atopic donors. Numbers of CCR4+ cells were up-regulated in T cell lines expanded in the presence of IL-4. CCR4 mRNA was absent at baseline in normal subjects in lung and skin, but present at baseline in the lung of some atopics. Baseline expression of CCR4 mRNA and protein was higher in lung vs. skin, but allergen-induced increases in CCR4 mRNA+ cells were observed in both organs. CCR4 protein+ cells were present at higher levels after allergen challenge in atopics compared to normal subjects. CCR4 may be important in the recruitment of T lymphocytes at sites of allergic inflammation, in a non-organ-specific manner.

Original language	English
Article number	N/A
Pages (from-to)	1933-1938
Number of pages	6
Journal	European Journal of Immunology
Volume	32
Issue number	7
DOIs	https://doi.org/10.1002/1521-4141(200207)32:7<1933::AID-IMMU1933>3.0.CO;2-R
Publication status	Published - Jul 2002

Keywords

Skin
Humans
Gene Expression
Asthma
Chemokine CCL22
Receptors, CCR4
Chemokine CCL17
Chemotaxis, Leukocyte
Receptors, Chemokine
CD4-Positive T-Lymphocytes
Lung
Antigens, CD3
Cells, Cultured
Rhinitis, Allergic, Seasonal
CD8-Positive T-Lymphocytes
Adult
Chemokines, CC
Hypersensitivity, Immediate
Male
Ligands
Cell Line
Female

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/1521-4141(200207)32:7<1933::AID-IMMU1933>3.0.CO;2-R

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Nouri-Aria, K. T., Wilson, D., Francis, J. N., Jopling, L. A., Jacobson, M. R., Hodge, M. R., Andrew, D. P., Till, S. J., Varga, E.-M., Williams, T. J., Pease, J. E., Lloyd, C. M., Sabroe, I., & Durham, S. R. (2002). CCR4 in human allergen-induced late responses in the skin and lung. European Journal of Immunology, 32(7), 1933-1938. Article N/A. https://doi.org/10.1002/1521-4141(200207)32:7<1933::AID-IMMU1933>3.0.CO;2-R

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title = "CCR4 in human allergen-induced late responses in the skin and lung",

abstract = "We studied the regulation of CCR4 expression in peripheral blood and in human models of cutaneous and pulmonary allergen challenge. CCR4 expression was detectable on freshly isolated CD4+ lymphocytes and in CD4+ and CD8+ T cell lines derived from blood of atopic donors. Numbers of CCR4+ cells were up-regulated in T cell lines expanded in the presence of IL-4. CCR4 mRNA was absent at baseline in normal subjects in lung and skin, but present at baseline in the lung of some atopics. Baseline expression of CCR4 mRNA and protein was higher in lung vs. skin, but allergen-induced increases in CCR4 mRNA+ cells were observed in both organs. CCR4 protein+ cells were present at higher levels after allergen challenge in atopics compared to normal subjects. CCR4 may be important in the recruitment of T lymphocytes at sites of allergic inflammation, in a non-organ-specific manner.",

keywords = "Skin, Humans, Gene Expression, Asthma, Chemokine CCL22, Receptors, CCR4, Chemokine CCL17, Chemotaxis, Leukocyte, Receptors, Chemokine, CD4-Positive T-Lymphocytes, Lung, Antigens, CD3, Cells, Cultured, Rhinitis, Allergic, Seasonal, CD8-Positive T-Lymphocytes, Adult, Chemokines, CC, Hypersensitivity, Immediate, Male, Ligands, Cell Line, Female",

author = "Nouri-Aria, {Kayhan T} and Duncan Wilson and Francis, {James N} and Jopling, {Louise A} and Jacobson, {Mikila R} and Hodge, {Martin R} and Andrew, {David P} and Till, {Stephen J} and Eva-Maria Varga and Williams, {Timothy J} and Pease, {James E} and Lloyd, {Clare M} and Ian Sabroe and Durham, {Stephen R}",

year = "2002",

month = jul,

doi = "10.1002/1521-4141(200207)32:7<1933::AID-IMMU1933>3.0.CO;2-R",

language = "English",

volume = "32",

pages = "1933--1938",

journal = "European Journal of Immunology",

issn = "0014-2980",

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Nouri-Aria, KT, Wilson, D, Francis, JN, Jopling, LA, Jacobson, MR, Hodge, MR, Andrew, DP, Till, SJ, Varga, E-M, Williams, TJ, Pease, JE, Lloyd, CM, Sabroe, I & Durham, SR 2002, 'CCR4 in human allergen-induced late responses in the skin and lung', European Journal of Immunology, vol. 32, no. 7, N/A, pp. 1933-1938. https://doi.org/10.1002/1521-4141(200207)32:7<1933::AID-IMMU1933>3.0.CO;2-R

TY - JOUR

T1 - CCR4 in human allergen-induced late responses in the skin and lung

AU - Nouri-Aria, Kayhan T

AU - Wilson, Duncan

AU - Francis, James N

AU - Jopling, Louise A

AU - Jacobson, Mikila R

AU - Hodge, Martin R

AU - Andrew, David P

AU - Till, Stephen J

AU - Varga, Eva-Maria

AU - Williams, Timothy J

AU - Pease, James E

AU - Lloyd, Clare M

AU - Sabroe, Ian

AU - Durham, Stephen R

PY - 2002/7

Y1 - 2002/7

N2 - We studied the regulation of CCR4 expression in peripheral blood and in human models of cutaneous and pulmonary allergen challenge. CCR4 expression was detectable on freshly isolated CD4+ lymphocytes and in CD4+ and CD8+ T cell lines derived from blood of atopic donors. Numbers of CCR4+ cells were up-regulated in T cell lines expanded in the presence of IL-4. CCR4 mRNA was absent at baseline in normal subjects in lung and skin, but present at baseline in the lung of some atopics. Baseline expression of CCR4 mRNA and protein was higher in lung vs. skin, but allergen-induced increases in CCR4 mRNA+ cells were observed in both organs. CCR4 protein+ cells were present at higher levels after allergen challenge in atopics compared to normal subjects. CCR4 may be important in the recruitment of T lymphocytes at sites of allergic inflammation, in a non-organ-specific manner.

AB - We studied the regulation of CCR4 expression in peripheral blood and in human models of cutaneous and pulmonary allergen challenge. CCR4 expression was detectable on freshly isolated CD4+ lymphocytes and in CD4+ and CD8+ T cell lines derived from blood of atopic donors. Numbers of CCR4+ cells were up-regulated in T cell lines expanded in the presence of IL-4. CCR4 mRNA was absent at baseline in normal subjects in lung and skin, but present at baseline in the lung of some atopics. Baseline expression of CCR4 mRNA and protein was higher in lung vs. skin, but allergen-induced increases in CCR4 mRNA+ cells were observed in both organs. CCR4 protein+ cells were present at higher levels after allergen challenge in atopics compared to normal subjects. CCR4 may be important in the recruitment of T lymphocytes at sites of allergic inflammation, in a non-organ-specific manner.

KW - Skin

KW - Humans

KW - Gene Expression

KW - Asthma

KW - Chemokine CCL22

KW - Receptors, CCR4

KW - Chemokine CCL17

KW - Chemotaxis, Leukocyte

KW - Receptors, Chemokine

KW - CD4-Positive T-Lymphocytes

KW - Lung

KW - Antigens, CD3

KW - Cells, Cultured

KW - Rhinitis, Allergic, Seasonal

KW - CD8-Positive T-Lymphocytes

KW - Adult

KW - Chemokines, CC

KW - Hypersensitivity, Immediate

KW - Male

KW - Ligands

KW - Cell Line

KW - Female

U2 - 10.1002/1521-4141(200207)32:7<1933::AID-IMMU1933>3.0.CO;2-R

DO - 10.1002/1521-4141(200207)32:7<1933::AID-IMMU1933>3.0.CO;2-R

M3 - Article

C2 - 12115613

SN - 0014-2980

VL - 32

SP - 1933

EP - 1938

JO - European Journal of Immunology

JF - European Journal of Immunology

IS - 7

M1 - N/A

ER -

CCR4 in human allergen-induced late responses in the skin and lung

Abstract

Keywords

UN SDGs

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