CD36 Is Significantly Correlated with Adipophilin in Human Carotid Lesions and Inversely Correlated with Plasma ApoAI

Sophie Collot-Teixeira, Calypso Barbatis, Florence Bultelle, Michael Koutouzis, Gerard Pasterkamp, Paul Fraser, Zenon S. Kyriakides, Robin N. Poston, Angelique Ristagno, Lilian McGregor, Chantal M. Boulanger, Guy Leseche, John L. McGregor

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

OxLDL uptake and cholesterol efflux inhibition in macrophages play a key role in atherosclerotic plaque formation, rupture, and thrombotic ischemia. This study investigates genes implicated in OxLDL uptake (CD36, SRA), cholesterol efflux inhibition (adipophilin, ADFP), and inflammatory recruitments of leukocytes (IL-8) in plaque lesion areas (PLAs) compared to nonplaque lesion areas (NPLAs) in human carotid endarterectomy specimens. Gene and protein expressions were assayed using quantitative PCR and quantitative immunohistochemistry. Pearson tests were used to investigate potential correlation between (a) different gene expressions and (b) gene expression and patient's plasma constituents. CD36, SRA, ADFP, and IL-8 were shown to be significantly more expressed in PLA compared to NPLA. In PLA, a significant correlation was observed between CD36, SRA, ADFP, and IL-8 mRNA levels. Moreover, CD36 expression level was significantly inversely correlated to plasma marker ApoAI. The above investigated genes/proteins may play a key role in the maturation of atherosclerotic lesions. Copyright (C) 2008 Sophie Collot-Teixeira et al.
Original languageEnglish
Article number813236
JournalJOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
Volume2008
Issue number1
Publication statusPublished - 2008

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