CD46: The 'multitasker' of complement proteins

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    81 Citations (Scopus)

    Abstract

    Complement is undeniably quintessential for innate immunity by detecting and eliminating infectious microorganisms. Recent work, however, highlights an equally profound impact of complement on the induction and regulation of a wide range of immune cells. In particular, the complement regulator CD46 emerges as a key sensor of immune activation and a vital modulator of adaptive immunity. In this review, we summarize the current knowledge of CD46-mediated signalling events and their functional consequences on immune-competent cells with a specific focus on those in CD4(+) T cells. We will also discuss the promises and challenges that potential therapeutic modulation of CD46 may hold and pose.
    Original languageEnglish
    Article numberN/A
    Pages (from-to)2808-2820
    Number of pages13
    JournalThe international journal of biochemistry & cell biology
    Volume45
    Issue number12
    DOIs
    Publication statusPublished - Dec 2013

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