CD4+CD25+ regulatory T-cell therapy

Shuiping Jiang; Robert I Lechler; Giovanna Lombardi

doi:10.1586/1744666X.2.3.387

CD4+CD25+ regulatory T-cell therapy

Shuiping Jiang, Robert I Lechler, Giovanna Lombardi

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor box P3 have been established as a key regulator for the control of autoimmunity. A growing body of experiments in animal models has provided compelling evidence that the adoptive transfer of CD4(+)CD25(+) Tregs can cure many autoimmune and allergic diseases, and appear to induce donor-specific transplantation tolerance. Thus, customer-tailored CD4(+)CD25(+) Tregs have emerged as potential reagents for adoptive cell therapy for individualized medicine. This review discusses recent advances towards that goal.

Original language	English
Pages (from-to)	387-392
Number of pages	6
Journal	Expert Review Of Clinical Immunology
Volume	2
Issue number	3
DOIs	https://doi.org/10.1586/1744666X.2.3.387
Publication status	Published - May 2006

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10.1586/1744666X.2.3.387

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title = "CD4+CD25+ regulatory T-cell therapy",

abstract = "Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor box P3 have been established as a key regulator for the control of autoimmunity. A growing body of experiments in animal models has provided compelling evidence that the adoptive transfer of CD4(+)CD25(+) Tregs can cure many autoimmune and allergic diseases, and appear to induce donor-specific transplantation tolerance. Thus, customer-tailored CD4(+)CD25(+) Tregs have emerged as potential reagents for adoptive cell therapy for individualized medicine. This review discusses recent advances towards that goal.",

author = "Shuiping Jiang and Lechler, {Robert I} and Giovanna Lombardi",

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AU - Lechler, Robert I

AU - Lombardi, Giovanna

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AB - Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor box P3 have been established as a key regulator for the control of autoimmunity. A growing body of experiments in animal models has provided compelling evidence that the adoptive transfer of CD4(+)CD25(+) Tregs can cure many autoimmune and allergic diseases, and appear to induce donor-specific transplantation tolerance. Thus, customer-tailored CD4(+)CD25(+) Tregs have emerged as potential reagents for adoptive cell therapy for individualized medicine. This review discusses recent advances towards that goal.

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DO - 10.1586/1744666X.2.3.387

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JO - Expert Review Of Clinical Immunology

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CD4+CD25+ regulatory T-cell therapy

Abstract

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