CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS)

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223 Citations (Scopus)

Abstract

Foxp3+ regulatory T cells (Tregs) play a central role in maintaining immune tolerance. A reduction in the function of Tregs is a key feature of autoimmune diseases, whereas their expansion in malignant diseases leads to the suppression of host antitumor responses. We analyzed the absolute number of CD4+ and CD8(+) Tregs in the peripheral blood of 52 patients with myelodysplastic syndrome (MDS) and show a significant correlation between increased number of CD4+ Tregs and MDS subgroups with 5% or more bone marrow blasts (P <.001), high International Prognostic Scoring System (IPSS) score (P <.001), and disease progression (P <.001), whereas no correlation between CD8+ Tregs and prognostic variables was observed. The CD4+ Tregs showed a polyclonal spectratype, and the percentage of the naive subset was significantly higher in the high-risk patients compared with low-risk or healthy age-matched donors (P = .032). Our data suggest that CD4+ Treg expansion is a feature of high-risk MDS and progression to aggressive subtypes of the disease.
Original languageEnglish
Article numberN/A
Pages (from-to)847-850
Number of pages4
JournalBlood
Volume110
Issue number3
Early online date5 Apr 2007
DOIs
Publication statusPublished - 1 Aug 2007

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