Cell-based studies of the molecular mechanism of muscle contraction

M. Irving*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)

Abstract

Structural, mechanical and biochemical investigations on isolated muscle fibers provide a cell-downwards approach to understanding molecular mechanisms in muscle contraction. Combined with the results of in vitro studies of the interaction between the myosin head domain, actin and ATP, this cell-based approach has led to a quantitative and dynamic description of muscle performance in terms of the interaction between individual myosin heads and actin filaments in the physiological environment of the muscle sarcomere.

Original languageEnglish
Title of host publicationComprehensive Biophysics
PublisherELSEVIER ACADEMIC PRESS INC
Pages191-225
Number of pages35
Volume4
ISBN (Print)9780080957180
DOIs
Publication statusPublished - 1 Dec 2012

Keywords

  • Actin
  • Muscle contraction
  • Muscle energetics
  • Muscle fiber
  • Muscle mechanics
  • Muscle physiology
  • Muscle regulation
  • Muscle structure
  • Myosin
  • Sarcomere
  • Skeletal muscle
  • Tropomyosin
  • Troponin
  • X-ray diffraction

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