Cell electrospinning cardiac patches for tissue engineering the heart

TY - JOUR

T1 - Cell electrospinning cardiac patches for tissue engineering the heart

AU - Ehler, Elisabeth

AU - Jayasinghe, Suwan N.

PY - 2014/9/21

Y1 - 2014/9/21

N2 - Cell electrospinning has tremendous applicability to a wide range of uses within both the laboratory and clinic. This has directly resulted from the technology's unique ability to immobilize multiple cell types with a wide range of molecules simultaneously within a fiber during the scaffold generation process. The technology has been shown to generate many cell laden complex architectures from true three-dimensional sheets to those multi-core vessels. Although those studies have demonstrated the versatility of this platform biotechnology, we show here for the first time the ability to immobilize primary cardiac myocytes within these fibers in our quest to develop this technology for creating three-dimensional cardiac patches which could be used for repairing, replacing and rejuvenating damaged, diseased and/or ageing cardiac tissues. These advances are unrivalled by any other technology currently available in the regenerative medicine toolbox, and have many interesting ramifications for repairing a damaged heart.

AB - Cell electrospinning has tremendous applicability to a wide range of uses within both the laboratory and clinic. This has directly resulted from the technology's unique ability to immobilize multiple cell types with a wide range of molecules simultaneously within a fiber during the scaffold generation process. The technology has been shown to generate many cell laden complex architectures from true three-dimensional sheets to those multi-core vessels. Although those studies have demonstrated the versatility of this platform biotechnology, we show here for the first time the ability to immobilize primary cardiac myocytes within these fibers in our quest to develop this technology for creating three-dimensional cardiac patches which could be used for repairing, replacing and rejuvenating damaged, diseased and/or ageing cardiac tissues. These advances are unrivalled by any other technology currently available in the regenerative medicine toolbox, and have many interesting ramifications for repairing a damaged heart.

KW - LIVING ORGANISMS

KW - IN-VIVO

KW - SCAFFOLDS

KW - ELECTROSURGERY

KW - MEDICINE

KW - FIBERS

U2 - 10.1039/c4an00766b

DO - 10.1039/c4an00766b

M3 - Article

SN - 0003-2654

VL - 139

SP - 4449

EP - 4452

JO - Analyst

JF - Analyst

IS - 18

ER -