Cell motility: Proline-rich proteins promote protrusions

M. R. Holt, A. Koffer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

137 Citations (Scopus)

Abstract

Many proline-rich proteins participate in delivering actin monomers to specific cellular locations where actin-rich membrane protrusions, such as ruffles, filopodia and microspikes, are formed. These protrusions are necessary for cell motility. Actin monomer is usually delivered to the site of polymerization in the form of profilactin - a complex of G-actin with a polyproline-binding protein, profilin. Here, we describe proline-rich proteins involved in regulating actin polymerization and classify them according to their role in recruiting profilin to the membrane.

Original languageEnglish
Pages (from-to)38-46
Number of pages9
JournalTRENDS IN CELL BIOLOGY
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Jan 2001

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