Cell Therapy in Dermatology

Gabriela Petrof; Alya Abdul Wahab; John A. McGrath

doi:10.1101/cshperspect.a015156

Cell Therapy in Dermatology

Gabriela Petrof, Alya Abdul Wahab, John A. McGrath^*

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Harnessing the regenerative capacity of keratinocytes and fibroblasts from human skin has created new opportunities to develop cell-based therapies for patients. Cultured cells and bioengineered skin products are being used to treat patients with inherited and acquired skin disorders associated with defective skin, and further clinical trials of new products are in progress. The capacity of extracutaneous sources of cells such as bone marrow is also being investigated for its plasticity in regenerating skin, and new strategies, such as the derivation of inducible pluripotent stem cells, also hold great promise for future cell therapies in dermatology. This article reviews some of the preclinical and clinical studies and future directions relating to cell therapy in dermatology, particularly for inherited skin diseases associated with fragile skin and poor wound healing.

Original language	English
Article number	015156
Number of pages	29
Journal	Cold Spring Harbor perspectives in medicine
Volume	4
Issue number	6
DOIs	https://doi.org/10.1101/cshperspect.a015156
Publication status	Published - Jun 2014

Keywords

DYSTROPHIC EPIDERMOLYSIS-BULLOSA
MESENCHYMAL STEM-CELLS
CULTURED DERMAL SUBSTITUTE
MARROW-DERIVED CELLS
INTRACTABLE SKIN ULCERS
PARTIAL-THICKNESS BURNS
PLACEBO-CONTROLLED TRIAL
SINGLE-CENTER EXPERIENCE
BONE-MARROW
VII COLLAGEN

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1101/cshperspect.a015156

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title = "Cell Therapy in Dermatology",

abstract = "Harnessing the regenerative capacity of keratinocytes and fibroblasts from human skin has created new opportunities to develop cell-based therapies for patients. Cultured cells and bioengineered skin products are being used to treat patients with inherited and acquired skin disorders associated with defective skin, and further clinical trials of new products are in progress. The capacity of extracutaneous sources of cells such as bone marrow is also being investigated for its plasticity in regenerating skin, and new strategies, such as the derivation of inducible pluripotent stem cells, also hold great promise for future cell therapies in dermatology. This article reviews some of the preclinical and clinical studies and future directions relating to cell therapy in dermatology, particularly for inherited skin diseases associated with fragile skin and poor wound healing.",

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author = "Gabriela Petrof and {Abdul Wahab}, Alya and McGrath, {John A.}",

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language = "English",

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journal = "Cold Spring Harbor perspectives in medicine",

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AU - Abdul Wahab, Alya

AU - McGrath, John A.

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N2 - Harnessing the regenerative capacity of keratinocytes and fibroblasts from human skin has created new opportunities to develop cell-based therapies for patients. Cultured cells and bioengineered skin products are being used to treat patients with inherited and acquired skin disorders associated with defective skin, and further clinical trials of new products are in progress. The capacity of extracutaneous sources of cells such as bone marrow is also being investigated for its plasticity in regenerating skin, and new strategies, such as the derivation of inducible pluripotent stem cells, also hold great promise for future cell therapies in dermatology. This article reviews some of the preclinical and clinical studies and future directions relating to cell therapy in dermatology, particularly for inherited skin diseases associated with fragile skin and poor wound healing.

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KW - MARROW-DERIVED CELLS

KW - INTRACTABLE SKIN ULCERS

KW - PARTIAL-THICKNESS BURNS

KW - PLACEBO-CONTROLLED TRIAL

KW - SINGLE-CENTER EXPERIENCE

KW - BONE-MARROW

KW - VII COLLAGEN

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Cell Therapy in Dermatology

Abstract

Keywords

UN SDGs

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