Cell transplantation strategies for retinal repair

E. L. West, R. A. Pearson, R. E. MacLaren, J. C. Sowden, R. R. Ali*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

84 Citations (Scopus)

Abstract

Cell transplantation is a novel therapeutic strategy to restore visual responses to the degenerate adult neural retina and represents an exciting area of regenerative neurotherapy. So far, it has been shown that transplanted postmitotic photoreceptor precursors are able to functionally integrate into the adult mouse neural retina. In this review, we discuss the differentiation of photoreceptor cells from both adult and embryonic-derived stem cells and their potential for retinal cell transplantation. We also discuss the strategies used to overcome barriers present in the degenerate neural retina and improve retinal cell integration. Finally, we consider the future translation of retinal cell therapy as a therapeutic strategy to treat retinal degeneration.

Original languageEnglish
Title of host publicationNeurotherapy
Subtitle of host publicationProgress in Restorative Neuroscience and Neurology
EditorsJoost Verhaagen, Elly Hol, Inge Huitenga, Jan Wijnholds, Arthur Bergen, Gerald Boer, Dick Swaab
Pages3-21
Number of pages19
DOIs
Publication statusPublished - 2009

Publication series

NameProgress in Brain Research
Volume175
ISSN (Print)0079-6123

Keywords

  • degeneration
  • photoreceptor
  • progenitor cell
  • retina
  • stem cell
  • transplantation

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