Cellular infiltration and cytokine mRNA expression in perennial allergic rhinitis

E M Varga; M R Jacobson; S J Till; K Masuyama; F O'Brien; S Rak; V Lund; G K Scadding; Q A Hamid; S R Durham

Cellular infiltration and cytokine mRNA expression in perennial allergic rhinitis

E M Varga, M R Jacobson, S J Till, K Masuyama, F O'Brien, S Rak, V Lund, G K Scadding, Q A Hamid, S R Durham

King's College London

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Allergen challenge in allergic rhinitis patients leads to local eosinophilia and Th2-type cytokine expression. Natural exposure to grass pollen is additionally characterized by epithelial mast-cell infiltration. We hypothesized that perennial allergic rhinitis is also associated with T-cell and eosinophil infiltration of the nasal mucosa, local Th2-type cytokine expression, and increased numbers of nasal epithelial mast cells.

Original language	English
Pages (from-to)	338-45
Number of pages	8
Journal	Allergy
Volume	54
Issue number	4
Publication status	Published - Apr 1999

Keywords

Macrophages
Humans
Receptors, Interleukin-2
RNA, Messenger
In Situ Hybridization
Rhinitis, Allergic, Perennial
Antigens, CD3
Eosinophils
Adult
Cytokines
Nasal Mucosa
Mast Cells
Immunohistochemistry
Female
Male
T-Lymphocytes

Cite this

@article{c593e9f5a5df4b17a3b52a4beb66445d,

title = "Cellular infiltration and cytokine mRNA expression in perennial allergic rhinitis",

abstract = "Allergen challenge in allergic rhinitis patients leads to local eosinophilia and Th2-type cytokine expression. Natural exposure to grass pollen is additionally characterized by epithelial mast-cell infiltration. We hypothesized that perennial allergic rhinitis is also associated with T-cell and eosinophil infiltration of the nasal mucosa, local Th2-type cytokine expression, and increased numbers of nasal epithelial mast cells.",

keywords = "Macrophages, Humans, Receptors, Interleukin-2, RNA, Messenger, In Situ Hybridization, Rhinitis, Allergic, Perennial, Antigens, CD3, Eosinophils, Adult, Cytokines, Nasal Mucosa, Mast Cells, Immunohistochemistry, Female, Male, T-Lymphocytes",

author = "Varga, {E M} and Jacobson, {M R} and Till, {S J} and K Masuyama and F O'Brien and S Rak and V Lund and Scadding, {G K} and Hamid, {Q A} and Durham, {S R}",

year = "1999",

month = apr,

language = "English",

volume = "54",

pages = "338--45",

journal = "Allergy",

issn = "0105-4538",

publisher = "Blackwell Publishing",

number = "4",

}

TY - JOUR

T1 - Cellular infiltration and cytokine mRNA expression in perennial allergic rhinitis

AU - Varga, E M

AU - Jacobson, M R

AU - Till, S J

AU - Masuyama, K

AU - O'Brien, F

AU - Rak, S

AU - Lund, V

AU - Scadding, G K

AU - Hamid, Q A

AU - Durham, S R

PY - 1999/4

Y1 - 1999/4

N2 - Allergen challenge in allergic rhinitis patients leads to local eosinophilia and Th2-type cytokine expression. Natural exposure to grass pollen is additionally characterized by epithelial mast-cell infiltration. We hypothesized that perennial allergic rhinitis is also associated with T-cell and eosinophil infiltration of the nasal mucosa, local Th2-type cytokine expression, and increased numbers of nasal epithelial mast cells.

AB - Allergen challenge in allergic rhinitis patients leads to local eosinophilia and Th2-type cytokine expression. Natural exposure to grass pollen is additionally characterized by epithelial mast-cell infiltration. We hypothesized that perennial allergic rhinitis is also associated with T-cell and eosinophil infiltration of the nasal mucosa, local Th2-type cytokine expression, and increased numbers of nasal epithelial mast cells.

KW - Macrophages

KW - Humans

KW - Receptors, Interleukin-2

KW - RNA, Messenger

KW - In Situ Hybridization

KW - Rhinitis, Allergic, Perennial

KW - Antigens, CD3

KW - Eosinophils

KW - Adult

KW - Cytokines

KW - Nasal Mucosa

KW - Mast Cells

KW - Immunohistochemistry

KW - Female

KW - Male

KW - T-Lymphocytes

M3 - Article

C2 - 10371092

SN - 0105-4538

VL - 54

SP - 338

EP - 345

JO - Allergy

JF - Allergy

IS - 4

ER -

Cellular infiltration and cytokine mRNA expression in perennial allergic rhinitis

Abstract

Keywords

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