TY - JOUR
T1 - Cellular Therapies in Pediatric Liver Diseases
AU - Vimalesvaran, Sunitha
AU - Nulty, Jessica
AU - Dhawan, Anil
PY - 2022/8/10
Y1 - 2022/8/10
N2 - Liver transplantation is the gold standard for the treatment of pediatric end-stage liver disease and liver based metabolic disorders. Although liver transplant is successful, its wider application is limited by shortage of donor organs, surgical complications, need for life long immunosuppressive medication and its associated complications. Cellular therapies such as hepatocytes and mesenchymal stromal cells (MSCs) are currently emerging as an attractive alternative to liver transplantation. The aim of this review is to present the existing world experience in hepatocyte and MSC transplantation and the potential for future effective applications of these modalities of treatment.
AB - Liver transplantation is the gold standard for the treatment of pediatric end-stage liver disease and liver based metabolic disorders. Although liver transplant is successful, its wider application is limited by shortage of donor organs, surgical complications, need for life long immunosuppressive medication and its associated complications. Cellular therapies such as hepatocytes and mesenchymal stromal cells (MSCs) are currently emerging as an attractive alternative to liver transplantation. The aim of this review is to present the existing world experience in hepatocyte and MSC transplantation and the potential for future effective applications of these modalities of treatment.
KW - acute liver failure
KW - hepatocyte transplantation
KW - mesenchymal stromal cell
KW - pediatric liver transplantation
UR - http://www.scopus.com/inward/record.url?scp=85137124330&partnerID=8YFLogxK
U2 - 10.3390/cells11162483
DO - 10.3390/cells11162483
M3 - Review article
C2 - 36010561
AN - SCOPUS:85137124330
SN - 2073-4409
VL - 11
JO - Cells
JF - Cells
IS - 16
M1 - 2483
ER -