Central nervous system involvement in the antiphospholipid (Hughes) syndrome

G Sanna; M L Bertolaccini; M J Cuadrado; M A Khamashta; G R V Hughes

doi:10.1093/rheumatology/keg080

Central nervous system involvement in the antiphospholipid (Hughes) syndrome

G Sanna, M L Bertolaccini, M J Cuadrado, M A Khamashta, G R V Hughes

Women & Children's Health

Research output: Contribution to journal › Literature review › peer-review

161 Citations (Scopus)

Abstract

The antiphospholipid (Hughes) syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy morbidity in the presence of anticardiolipin antibodies and/or lupus anticoagulant. APS can occur either as a primary disorder or secondary to a connective tissue disease, most frequently systemic lupus erythematosus. Central nervous system (CNS) involvement is one of the most prominent clinical manifestations of APS, and includes arterial and venous thrombotic events, psychiatric features and a variety of other non-thrombotic neurological syndromes. In this review we focus on the common and some of the less common CNS manifestations that have been reported in association with antiphospholipid antibodies.

Original language	English
Article number	N/A
Pages (from-to)	200 - 213
Number of pages	14
Journal	Rheumatology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1093/rheumatology/keg080
Publication status	Published - Feb 2003

Keywords

Antiphospholipid Syndrome
Brain Diseases
Cerebrovascular Disorders
Epilepsy
Headache Disorders
Humans
Mental Disorders

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10.1093/rheumatology/keg080

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abstract = "The antiphospholipid (Hughes) syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy morbidity in the presence of anticardiolipin antibodies and/or lupus anticoagulant. APS can occur either as a primary disorder or secondary to a connective tissue disease, most frequently systemic lupus erythematosus. Central nervous system (CNS) involvement is one of the most prominent clinical manifestations of APS, and includes arterial and venous thrombotic events, psychiatric features and a variety of other non-thrombotic neurological syndromes. In this review we focus on the common and some of the less common CNS manifestations that have been reported in association with antiphospholipid antibodies.",

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AU - Sanna, G

AU - Bertolaccini, M L

AU - Cuadrado, M J

AU - Khamashta, M A

AU - Hughes, G R V

PY - 2003/2

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N2 - The antiphospholipid (Hughes) syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy morbidity in the presence of anticardiolipin antibodies and/or lupus anticoagulant. APS can occur either as a primary disorder or secondary to a connective tissue disease, most frequently systemic lupus erythematosus. Central nervous system (CNS) involvement is one of the most prominent clinical manifestations of APS, and includes arterial and venous thrombotic events, psychiatric features and a variety of other non-thrombotic neurological syndromes. In this review we focus on the common and some of the less common CNS manifestations that have been reported in association with antiphospholipid antibodies.

AB - The antiphospholipid (Hughes) syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy morbidity in the presence of anticardiolipin antibodies and/or lupus anticoagulant. APS can occur either as a primary disorder or secondary to a connective tissue disease, most frequently systemic lupus erythematosus. Central nervous system (CNS) involvement is one of the most prominent clinical manifestations of APS, and includes arterial and venous thrombotic events, psychiatric features and a variety of other non-thrombotic neurological syndromes. In this review we focus on the common and some of the less common CNS manifestations that have been reported in association with antiphospholipid antibodies.

KW - Antiphospholipid Syndrome

KW - Brain Diseases

KW - Cerebrovascular Disorders

KW - Epilepsy

KW - Headache Disorders

KW - Humans

KW - Mental Disorders

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M3 - Literature review

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JO - Rheumatology

JF - Rheumatology

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Central nervous system involvement in the antiphospholipid (Hughes) syndrome

Abstract

Keywords

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