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Cerclage position, cervical length and preterm delivery in women undergoing ultrasound indicated cervical cerclage: A retrospective cohort study

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Joanna R. Cook, Susan Chatfield, Manju Chandiramani, Lindsay Kindinger, Stefano Cacciatore, Lynne Sykes, Tiong Teoh, Andrew Shennan, Vasso Terzidou, Phillip R. Bennett

Original languageEnglish
Article numbere0178072
Number of pages9
JournalPL o S One
Volume12
Issue number6
Early online date1 Jun 2017
DOIs
Accepted/In press5 May 2017
E-pub ahead of print1 Jun 2017

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Abstract

Objective The objectives were to assess whether anatomical location of ultrasound (USS) indicated cervical cerclage and/or the degree of cervical shortening (cervical length; CL) prior to and following cerclage affects the risk of preterm birth (PTB). Method A retrospective cohort study of 179 women receiving cerclage for short cervix (25mm) was performed. Demographic data, CL before and after cerclage insertion, height of cerclage (distance from external os) and gestation at delivery were collected. Relative risk (RR) and odds ratio (OR) of preterm delivery were calculated according to the anatomical location of the cerclage within the cervix and the CL before and after cerclage as categorical and continuous variables. Partition tree analysis was used to identify the threshold cerclage height that best predicts PTB. Results 25% (n = 45) delivered <34 weeks and 36% (n = 65) delivered <37 weeks. Risk of PTB was greater with cerclage in the distal 10mm (RR2.37, 95% CI 1.45±3.87) or the distal half of a closed cervix (RR2.16, 95% CI 1.45±3.87). Increasing absolute cerclage height was associated with a reduction in PTB (OR 0.87, 95% CI 0.82±0.94). A cerclage height <14.5 mm best predicts PTB (70.8%). Increasing CL following cerclage was associated with a reduction in PTB (OR0.87, 95% CI 0.82±0.94). Conversely, the risk of PTB was increased where CL remained static or shortened further following cerclage (RR2.34, 95% CI 1.04± Conclusion The higher a cerclage was placed within a shortened cervix, the lower the subsequent odds of PTB. Women whose cerclage is placed in the distal 10mm of closed cervix or whose cervix fails to elongate subsequently, should remain under close surveillance as they have the highest risk of PTB.

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