Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorder

Erwin Lemche; Ananthapadmanabha Anilkumar; Vincent Giampietro; Michael J. Brammer; Simon A. Surguladze; Natalia S. Lawrence; David Gasston; Xavier Chitnis; Steven C. R. Williams; Mauricio Sierra; Peter Joraschky; Mary L. Phillips

doi:10.1192/bjp.bp,107.044263

Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorder

Erwin Lemche, Ananthapadmanabha Anilkumar, Vincent Giampietro, Michael J. Brammer, Simon A. Surguladze, Natalia S. Lawrence, David Gasston, Xavier Chitnis, Steven C. R. Williams, Mauricio Sierra, Peter Joraschky, Mary L. Phillips

Research output: Contribution to journal › Article › peer-review

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Abstract

Background Depersonalisation disorder is characterised by emotion suppression, but the cerebral mechanisms of this symptom are not yet fully understood. Aims To compare brain activation and autonomic responses of individuals with the disorder and healthy controls. Method Happy and sad emotion expressions in increasing intensities (neutral to intense) were presented in an implicit event-related functional magnetic resonance imaging (fMRI) design with simultaneous measurement of autonomic responses. Results Participants with depersonalisation disorder showed fMRI signal decreases, whereas the control group showed signal increases in response to emotion intensity increases in both happy and sad expressions. The analysis of evoked haemodynamic responses from regions exhibiting functional connectivity between central and autonomic nervous systems indicated that in depersonalisation disorder initial modulations of haemodynamic response occurred significantly earlier (2 s post-stimulus) than in the control group (4-6 s post-stimulus). Conclusions The results suggest that fMRI signal decreases are possible correlates of emotion suppression in depersonalisation disorder.

Original language	English
Pages (from-to)	222 - 228
Number of pages	7
Journal	British Journal of Psychiatry
Volume	193
Issue number	3
DOIs	https://doi.org/10.1192/bjp.bp,107.044263
Publication status	Published - Sept 2008

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Lemche, E., Anilkumar, A., Giampietro, V., Brammer, M. J., Surguladze, S. A., Lawrence, N. S., Gasston, D., Chitnis, X., Williams, S. C. R., Sierra, M., Joraschky, P., & Phillips, M. L. (2008). Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorder. British Journal of Psychiatry, 193(3), 222 - 228. https://doi.org/10.1192/bjp.bp,107.044263

@article{e3068f71b27745c8b69c5ca4f550c578,

title = "Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorder",

abstract = "Background Depersonalisation disorder is characterised by emotion suppression, but the cerebral mechanisms of this symptom are not yet fully understood. Aims To compare brain activation and autonomic responses of individuals with the disorder and healthy controls. Method Happy and sad emotion expressions in increasing intensities (neutral to intense) were presented in an implicit event-related functional magnetic resonance imaging (fMRI) design with simultaneous measurement of autonomic responses. Results Participants with depersonalisation disorder showed fMRI signal decreases, whereas the control group showed signal increases in response to emotion intensity increases in both happy and sad expressions. The analysis of evoked haemodynamic responses from regions exhibiting functional connectivity between central and autonomic nervous systems indicated that in depersonalisation disorder initial modulations of haemodynamic response occurred significantly earlier (2 s post-stimulus) than in the control group (4-6 s post-stimulus). Conclusions The results suggest that fMRI signal decreases are possible correlates of emotion suppression in depersonalisation disorder.",

author = "Erwin Lemche and Ananthapadmanabha Anilkumar and Vincent Giampietro and Brammer, {Michael J.} and Surguladze, {Simon A.} and Lawrence, {Natalia S.} and David Gasston and Xavier Chitnis and Williams, {Steven C. R.} and Mauricio Sierra and Peter Joraschky and Phillips, {Mary L.}",

year = "2008",

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doi = "10.1192/bjp.bp,107.044263",

language = "English",

volume = "193",

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journal = "British Journal of Psychiatry",

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TY - JOUR

T1 - Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorder

AU - Lemche, Erwin

AU - Anilkumar, Ananthapadmanabha

AU - Giampietro, Vincent

AU - Brammer, Michael J.

AU - Surguladze, Simon A.

AU - Lawrence, Natalia S.

AU - Gasston, David

AU - Chitnis, Xavier

AU - Williams, Steven C. R.

AU - Sierra, Mauricio

AU - Joraschky, Peter

AU - Phillips, Mary L.

PY - 2008/9

Y1 - 2008/9

N2 - Background Depersonalisation disorder is characterised by emotion suppression, but the cerebral mechanisms of this symptom are not yet fully understood. Aims To compare brain activation and autonomic responses of individuals with the disorder and healthy controls. Method Happy and sad emotion expressions in increasing intensities (neutral to intense) were presented in an implicit event-related functional magnetic resonance imaging (fMRI) design with simultaneous measurement of autonomic responses. Results Participants with depersonalisation disorder showed fMRI signal decreases, whereas the control group showed signal increases in response to emotion intensity increases in both happy and sad expressions. The analysis of evoked haemodynamic responses from regions exhibiting functional connectivity between central and autonomic nervous systems indicated that in depersonalisation disorder initial modulations of haemodynamic response occurred significantly earlier (2 s post-stimulus) than in the control group (4-6 s post-stimulus). Conclusions The results suggest that fMRI signal decreases are possible correlates of emotion suppression in depersonalisation disorder.

AB - Background Depersonalisation disorder is characterised by emotion suppression, but the cerebral mechanisms of this symptom are not yet fully understood. Aims To compare brain activation and autonomic responses of individuals with the disorder and healthy controls. Method Happy and sad emotion expressions in increasing intensities (neutral to intense) were presented in an implicit event-related functional magnetic resonance imaging (fMRI) design with simultaneous measurement of autonomic responses. Results Participants with depersonalisation disorder showed fMRI signal decreases, whereas the control group showed signal increases in response to emotion intensity increases in both happy and sad expressions. The analysis of evoked haemodynamic responses from regions exhibiting functional connectivity between central and autonomic nervous systems indicated that in depersonalisation disorder initial modulations of haemodynamic response occurred significantly earlier (2 s post-stimulus) than in the control group (4-6 s post-stimulus). Conclusions The results suggest that fMRI signal decreases are possible correlates of emotion suppression in depersonalisation disorder.

U2 - 10.1192/bjp.bp,107.044263

DO - 10.1192/bjp.bp,107.044263

M3 - Article

SN - 1472-1465

VL - 193

SP - 222

EP - 228

JO - British Journal of Psychiatry

JF - British Journal of Psychiatry

IS - 3

ER -

Cerebral and autonomic responses to emotional facial expressions in depersonalisation disorder

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