Cerebral cavernoma: an emerging long-term consequence of external beam radiation in childhood

Y. Liu; R. Preston; S. M. Thomas; A. Brackenridge; P. V. Carroll

doi:10.1111/j.1365-2265.2009.03767.x

Cerebral cavernoma: an emerging long-term consequence of external beam radiation in childhood

Y. Liu^*, R. Preston, S. M. Thomas, A. Brackenridge, P. V. Carroll

^*Corresponding author for this work

GSTT Guy's and St Thomas' NHS Foundation Trust

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The long-term effects of cranial external beam radiotherapy are emerging as survival rates for cerebral tumours improve. Cerebral cavernoma are a recognized consequence of cranial irradiation. Endocrinologists managing the life-long complications of hypopituitarism associated with irradiation need to be aware and vigilant of the risks of cavernoma formation, in particular in the population with a history of childhood irradiation. We present three cases of young patients who were diagnosed with cerebral cavernoma many years after childhood irradiation treatment and review the current literature on this condition. We discuss implications for endocrine practice as rising numbers of patients survive childhood cancer and irradiation and are now attending adult endocrine services for long-term management of secondary hypopituitarism.

Original language	English
Pages (from-to)	555-560
Number of pages	6
Journal	Clinical endocrinology
Volume	73
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2265.2009.03767.x
Publication status	Published - Nov 2010

Keywords

BRAIN-TUMORS
NATURAL-HISTORY
CRANIAL IRRADIATION
MALFORMATIONS
CHILDREN
COMPLICATIONS
HEMANGIOMA
SURVIVORS
ANGIOMA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-2265.2009.03767.x

Cite this

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title = "Cerebral cavernoma: an emerging long-term consequence of external beam radiation in childhood",

abstract = "The long-term effects of cranial external beam radiotherapy are emerging as survival rates for cerebral tumours improve. Cerebral cavernoma are a recognized consequence of cranial irradiation. Endocrinologists managing the life-long complications of hypopituitarism associated with irradiation need to be aware and vigilant of the risks of cavernoma formation, in particular in the population with a history of childhood irradiation. We present three cases of young patients who were diagnosed with cerebral cavernoma many years after childhood irradiation treatment and review the current literature on this condition. We discuss implications for endocrine practice as rising numbers of patients survive childhood cancer and irradiation and are now attending adult endocrine services for long-term management of secondary hypopituitarism.",

keywords = "BRAIN-TUMORS, NATURAL-HISTORY, CRANIAL IRRADIATION, MALFORMATIONS, CHILDREN, COMPLICATIONS, HEMANGIOMA, SURVIVORS, ANGIOMA",

author = "Y. Liu and R. Preston and Thomas, {S. M.} and A. Brackenridge and Carroll, {P. V.}",

year = "2010",

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doi = "10.1111/j.1365-2265.2009.03767.x",

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journal = "Clinical endocrinology",

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T2 - an emerging long-term consequence of external beam radiation in childhood

AU - Liu, Y.

AU - Preston, R.

AU - Thomas, S. M.

AU - Brackenridge, A.

AU - Carroll, P. V.

PY - 2010/11

Y1 - 2010/11

N2 - The long-term effects of cranial external beam radiotherapy are emerging as survival rates for cerebral tumours improve. Cerebral cavernoma are a recognized consequence of cranial irradiation. Endocrinologists managing the life-long complications of hypopituitarism associated with irradiation need to be aware and vigilant of the risks of cavernoma formation, in particular in the population with a history of childhood irradiation. We present three cases of young patients who were diagnosed with cerebral cavernoma many years after childhood irradiation treatment and review the current literature on this condition. We discuss implications for endocrine practice as rising numbers of patients survive childhood cancer and irradiation and are now attending adult endocrine services for long-term management of secondary hypopituitarism.

AB - The long-term effects of cranial external beam radiotherapy are emerging as survival rates for cerebral tumours improve. Cerebral cavernoma are a recognized consequence of cranial irradiation. Endocrinologists managing the life-long complications of hypopituitarism associated with irradiation need to be aware and vigilant of the risks of cavernoma formation, in particular in the population with a history of childhood irradiation. We present three cases of young patients who were diagnosed with cerebral cavernoma many years after childhood irradiation treatment and review the current literature on this condition. We discuss implications for endocrine practice as rising numbers of patients survive childhood cancer and irradiation and are now attending adult endocrine services for long-term management of secondary hypopituitarism.

KW - BRAIN-TUMORS

KW - NATURAL-HISTORY

KW - CRANIAL IRRADIATION

KW - MALFORMATIONS

KW - CHILDREN

KW - COMPLICATIONS

KW - HEMANGIOMA

KW - SURVIVORS

KW - ANGIOMA

U2 - 10.1111/j.1365-2265.2009.03767.x

DO - 10.1111/j.1365-2265.2009.03767.x

M3 - Article

SN - 0300-0664

VL - 73

SP - 555

EP - 560

JO - Clinical endocrinology

JF - Clinical endocrinology

IS - 5

ER -

Cerebral cavernoma: an emerging long-term consequence of external beam radiation in childhood

Abstract

Keywords

UN SDGs

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