Cerebral palsy

TY - JOUR

T1 - Cerebral palsy

AU - Colver, Allan

AU - Fairhurst, Charlie

AU - Pharoah, Peter O. D.

PY - 2014/4/5

Y1 - 2014/4/5

N2 - The syndrome of cerebral palsy encompasses a large group of childhood movement and posture disorders. Severity, patterns of motor involvement, and associated impairments such as those of communication, intellectual ability, and epilepsy vary widely. Overall prevalence has remained stable in the past 40 years at 2-3.5 cases per 1000 livebirths, despite changes in antenatal and perinatal care. The few studies available from developing countries suggest prevalence of comparable magnitude. Cerebral palsy is a lifelong disorder; approaches to intervention, whether at an individual or environmental level, should recognise that quality of life and social participation throughout life are what individuals with cerebral palsy seek, not improved physical function for its own sake. In the past few years, the cerebral palsy community has learned that the evidence of benefit for the numerous drugs, surgery, and therapies used over previous decades is weak. Improved understanding of the role of multiple gestation in pathogenesis, of gene environment interaction, and how to influence brain plasticity could yield significant advances in treatment of the disorder. Reduction in the prevalence of post-neonatal cerebral palsy, especially in developing countries, should be possible through improved nutrition, infection control, and accident prevention.

AB - The syndrome of cerebral palsy encompasses a large group of childhood movement and posture disorders. Severity, patterns of motor involvement, and associated impairments such as those of communication, intellectual ability, and epilepsy vary widely. Overall prevalence has remained stable in the past 40 years at 2-3.5 cases per 1000 livebirths, despite changes in antenatal and perinatal care. The few studies available from developing countries suggest prevalence of comparable magnitude. Cerebral palsy is a lifelong disorder; approaches to intervention, whether at an individual or environmental level, should recognise that quality of life and social participation throughout life are what individuals with cerebral palsy seek, not improved physical function for its own sake. In the past few years, the cerebral palsy community has learned that the evidence of benefit for the numerous drugs, surgery, and therapies used over previous decades is weak. Improved understanding of the role of multiple gestation in pathogenesis, of gene environment interaction, and how to influence brain plasticity could yield significant advances in treatment of the disorder. Reduction in the prevalence of post-neonatal cerebral palsy, especially in developing countries, should be possible through improved nutrition, infection control, and accident prevention.

KW - QUALITY-OF-LIFE

KW - SELECTIVE DORSAL RHIZOTOMY

KW - HYPOXIC-ISCHEMIC ENCEPHALOPATHY

KW - RANDOMIZED CONTROLLED-TRIAL

KW - DEEP BRAIN-STIMULATION

KW - YOUNG-CHILDREN

KW - CONGENITAL-ANOMALIES

KW - WESTERN-AUSTRALIA

KW - 8-12-YEAR-OLD CHILDREN

KW - CLASSIFICATION-SYSTEM

U2 - 10.1016/S0140-6736(13)61835-8

DO - 10.1016/S0140-6736(13)61835-8

M3 - Article

SN - 0140-6736

VL - 383

SP - 1240

EP - 1249

JO - The Lancet

JF - The Lancet

IS - 9924

ER -