Cerebrospinal luid viral escape and acute encephalitis in a patient on boosted protease inhibitor monotherapy

Juan Tiraboschi; Lisa Hamzah; Ata Siddiqui; Ranjababu Kulasegaram; Frank Post; Julie Fox

doi:10.3851/IMP3021

Cerebrospinal luid viral escape and acute encephalitis in a patient on boosted protease inhibitor monotherapy

Juan Tiraboschi^*, Lisa Hamzah, Ata Siddiqui, Ranjababu Kulasegaram, Frank Post, Julie Fox

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Although currently available data sufice to support the use of protease inhibitor monotherapy in selected patients, there is concern about the antiviral activity of this regimen in the long term and in viral sanctuaries, such as the central nervous system. We report a case of encephalitis related to viral escape while receiving darunavir/ritonavir monotherapy in a carefully selected patient for participation in a clinical trial.

Original language	English
Pages (from-to)	461-464
Number of pages	4
Journal	ANTIVIRAL THERAPY
Volume	21
Issue number	5
Early online date	6 Jan 2016
DOIs	https://doi.org/10.3851/IMP3021
Publication status	Published - 1 Oct 2016

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abstract = "Although currently available data sufice to support the use of protease inhibitor monotherapy in selected patients, there is concern about the antiviral activity of this regimen in the long term and in viral sanctuaries, such as the central nervous system. We report a case of encephalitis related to viral escape while receiving darunavir/ritonavir monotherapy in a carefully selected patient for participation in a clinical trial.",

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AU - Tiraboschi, Juan

AU - Hamzah, Lisa

AU - Siddiqui, Ata

AU - Kulasegaram, Ranjababu

AU - Post, Frank

AU - Fox, Julie

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AB - Although currently available data sufice to support the use of protease inhibitor monotherapy in selected patients, there is concern about the antiviral activity of this regimen in the long term and in viral sanctuaries, such as the central nervous system. We report a case of encephalitis related to viral escape while receiving darunavir/ritonavir monotherapy in a carefully selected patient for participation in a clinical trial.

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Cerebrospinal luid viral escape and acute encephalitis in a patient on boosted protease inhibitor monotherapy

Abstract

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