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Cerebrospinal luid viral escape and acute encephalitis in a patient on boosted protease inhibitor monotherapy

Research output: Contribution to journalArticlepeer-review

Juan Tiraboschi, Lisa Hamzah, Ata Siddiqui, Ranjababu Kulasegaram, Frank Post, Julie Fox

Original languageEnglish
Pages (from-to)461-464
Number of pages4
Issue number5
Early online date6 Jan 2016
Accepted/In press14 Dec 2015
E-pub ahead of print6 Jan 2016
Published1 Oct 2016

King's Authors


Although currently available data sufice to support the use of protease inhibitor monotherapy in selected patients, there is concern about the antiviral activity of this regimen in the long term and in viral sanctuaries, such as the central nervous system. We report a case of encephalitis related to viral escape while receiving darunavir/ritonavir monotherapy in a carefully selected patient for participation in a clinical trial.

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