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Cervicovaginal natural antimicrobial expression in pregnancy and association with spontaneous preterm birth

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Cervicovaginal natural antimicrobial expression in pregnancy and association with spontaneous preterm birth. / Hezelgrave, Natasha L; Seed, Paul T; Chin-Smith, Evonne C; Ridout, Alexandra E; Shennan, Andrew H; Tribe, Rachel M.

In: Scientific Reports, Vol. 10, No. 1, 12018, 01.12.2020.

Research output: Contribution to journalArticle

Harvard

Hezelgrave, NL, Seed, PT, Chin-Smith, EC, Ridout, AE, Shennan, AH & Tribe, RM 2020, 'Cervicovaginal natural antimicrobial expression in pregnancy and association with spontaneous preterm birth', Scientific Reports, vol. 10, no. 1, 12018. https://doi.org/10.1038/s41598-020-68329-z

APA

Hezelgrave, N. L., Seed, P. T., Chin-Smith, E. C., Ridout, A. E., Shennan, A. H., & Tribe, R. M. (2020). Cervicovaginal natural antimicrobial expression in pregnancy and association with spontaneous preterm birth. Scientific Reports, 10(1), [12018]. https://doi.org/10.1038/s41598-020-68329-z

Vancouver

Hezelgrave NL, Seed PT, Chin-Smith EC, Ridout AE, Shennan AH, Tribe RM. Cervicovaginal natural antimicrobial expression in pregnancy and association with spontaneous preterm birth. Scientific Reports. 2020 Dec 1;10(1). 12018. https://doi.org/10.1038/s41598-020-68329-z

Author

Hezelgrave, Natasha L ; Seed, Paul T ; Chin-Smith, Evonne C ; Ridout, Alexandra E ; Shennan, Andrew H ; Tribe, Rachel M. / Cervicovaginal natural antimicrobial expression in pregnancy and association with spontaneous preterm birth. In: Scientific Reports. 2020 ; Vol. 10, No. 1.

Bibtex Download

@article{be8b30443ab3419f8a2f59660b5ffb22,
title = "Cervicovaginal natural antimicrobial expression in pregnancy and association with spontaneous preterm birth",
abstract = "There is much interest in the role of innate immune system proteins (antimicrobial peptides) in the inflammatory process associated with spontaneous preterm birth (sPTB). After promising pilot work, we aimed to validate the association between the antimicrobial peptides/proteins elafin and cathelicidin and sPTB. An observational cohort study of 405 women at high-risk, and 214 women at low-risk of sPTB. Protein concentrations of elafin and cathelicidin, and the enzyme human neutrophil elastase (HNE) were measured in over 1,000 cervicovaginal fluid (CVF) samples (10 to 24 weeks{\textquoteright} gestation). Adjusted CVF cathelicidin and HNE concentrations (but not elafin) were raised in high-risk women who developed cervical shortening and who delivered prematurely and were predictive of sPTB < 37 weeks, with an area under the curve (AUC) of 0.75 (95% CI 0.68 to 0.81) for cathelicidin concentration at 14 to 15+6 weeks. Elafin concentrations were affected by gestation, body mass index and smoking. CVF elafin in early pregnancy was modestly predictive of sPTB < 34 weeks (AUC 0.63, 0.56–0.70). Alterations in innate immune response proteins in early pregnancy are predictive of sPTB. Further investigation is warranted to understand the drivers for this, and their potential to contribute towards clinically useful prediction techniques.",
author = "Hezelgrave, {Natasha L} and Seed, {Paul T} and Chin-Smith, {Evonne C} and Ridout, {Alexandra E} and Shennan, {Andrew H} and Tribe, {Rachel M}",
year = "2020",
month = dec,
day = "1",
doi = "10.1038/s41598-020-68329-z",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Cervicovaginal natural antimicrobial expression in pregnancy and association with spontaneous preterm birth

AU - Hezelgrave, Natasha L

AU - Seed, Paul T

AU - Chin-Smith, Evonne C

AU - Ridout, Alexandra E

AU - Shennan, Andrew H

AU - Tribe, Rachel M

PY - 2020/12/1

Y1 - 2020/12/1

N2 - There is much interest in the role of innate immune system proteins (antimicrobial peptides) in the inflammatory process associated with spontaneous preterm birth (sPTB). After promising pilot work, we aimed to validate the association between the antimicrobial peptides/proteins elafin and cathelicidin and sPTB. An observational cohort study of 405 women at high-risk, and 214 women at low-risk of sPTB. Protein concentrations of elafin and cathelicidin, and the enzyme human neutrophil elastase (HNE) were measured in over 1,000 cervicovaginal fluid (CVF) samples (10 to 24 weeks’ gestation). Adjusted CVF cathelicidin and HNE concentrations (but not elafin) were raised in high-risk women who developed cervical shortening and who delivered prematurely and were predictive of sPTB < 37 weeks, with an area under the curve (AUC) of 0.75 (95% CI 0.68 to 0.81) for cathelicidin concentration at 14 to 15+6 weeks. Elafin concentrations were affected by gestation, body mass index and smoking. CVF elafin in early pregnancy was modestly predictive of sPTB < 34 weeks (AUC 0.63, 0.56–0.70). Alterations in innate immune response proteins in early pregnancy are predictive of sPTB. Further investigation is warranted to understand the drivers for this, and their potential to contribute towards clinically useful prediction techniques.

AB - There is much interest in the role of innate immune system proteins (antimicrobial peptides) in the inflammatory process associated with spontaneous preterm birth (sPTB). After promising pilot work, we aimed to validate the association between the antimicrobial peptides/proteins elafin and cathelicidin and sPTB. An observational cohort study of 405 women at high-risk, and 214 women at low-risk of sPTB. Protein concentrations of elafin and cathelicidin, and the enzyme human neutrophil elastase (HNE) were measured in over 1,000 cervicovaginal fluid (CVF) samples (10 to 24 weeks’ gestation). Adjusted CVF cathelicidin and HNE concentrations (but not elafin) were raised in high-risk women who developed cervical shortening and who delivered prematurely and were predictive of sPTB < 37 weeks, with an area under the curve (AUC) of 0.75 (95% CI 0.68 to 0.81) for cathelicidin concentration at 14 to 15+6 weeks. Elafin concentrations were affected by gestation, body mass index and smoking. CVF elafin in early pregnancy was modestly predictive of sPTB < 34 weeks (AUC 0.63, 0.56–0.70). Alterations in innate immune response proteins in early pregnancy are predictive of sPTB. Further investigation is warranted to understand the drivers for this, and their potential to contribute towards clinically useful prediction techniques.

UR - http://www.scopus.com/inward/record.url?scp=85088300193&partnerID=8YFLogxK

U2 - 10.1038/s41598-020-68329-z

DO - 10.1038/s41598-020-68329-z

M3 - Article

C2 - 32694552

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 12018

ER -

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