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CGRP discovery and timeline

Research output: Chapter in Book/Report/Conference proceedingChapter

Kate Arkless, Fulye Argunhan, Susan D. Brain

Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
PublisherSpringer New York LLC
Pages1-12
Number of pages12
DOIs
Publication statusPublished - 1 Jan 2019

Publication series

NameHandbook of Experimental Pharmacology
Volume255
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

King's Authors

Abstract

Calcitonin gene-related peptide (CGRP) was discovered over about 35 years ago through molecular biological techniques. Its activity as a vasodilator and the proposal that it was involved in pain processing were then soon established. Today, we are in the interesting situation of having the approval for the clinical use of antagonists and antibodies that have proved to block CGRP activities and benefit migraine. Despite all, there is still much to learn concerning the relevance of the vasodilator and other activities as well as further potential applications of CGRP agonists and blockers in disease. This review aims to discuss the history and present knowledge and to act as an introductory chapter in this volume.

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