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Challenges and opportunities for system biology standards and tools in medical research

Research output: Chapter in Book/Report/Conference proceedingConference paper

Matthias König, Anika Oellrich, Dagmar Waltemath, Richard J B Dobson, Tim J P Hubbard, Olaf Wolkenhauer

Original languageEnglish
Title of host publicationProceedings of the 7th Workshop on Ontologies and Data in Life Sciences, organized by the GI Workgroup Ontologies in Biomedicine and Life Sciences
StatePublished - 29 Sep 2016
Event7th Workshop on Ontologies and Data in Life Sciences, ODLS 2016 - Halle (Saale), Germany
Duration: 29 Sep 201630 Sep 2016


Conference7th Workshop on Ontologies and Data in Life Sciences, ODLS 2016
CityHalle (Saale)



King's Authors


Kinetic models are increasingly relevant in medical research. In systems biology, more than 10 years of experience with the development of standards and tools to construct and analyse kinetic models exists. This has supported the sharing of kinetic models, increased their reuse, and thereby has helped to reproduce and validate scientific results. Given this expertise, it seems natural to consider the application and development of standards and tools to meet the requirements of medical scientists. In this paper, we discuss challenges and opportunities for standards and tools from systems biology in medical research, and we suggest criteria for the safe use of simulations. We conclude that standards, tools and infrastructure need to be extended to ensure the quality, reliability and safety required when working with medical and patient data. This will foster the adaptation of modelling in the clinic, providing tools for improved diagnosis, prognosis and therapy.

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