Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine

Francesco Matrisciano; Stefania Bonaccorso; Angelo Ricciardi; Sergio Scaccianoce; Isabella Panaccione; Lily Wang; Amedo Ruberto; Roberto Tatarelli; Ferdinando Nicoletti; Paolo Girardi; Richard C. Shelton

doi:10.1016/j.jpsychires.2008.03.014

Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine

Francesco Matrisciano, Stefania Bonaccorso, Angelo Ricciardi, Sergio Scaccianoce, Isabella Panaccione, Lily Wang, Amedo Ruberto, Roberto Tatarelli, Ferdinando Nicoletti, Paolo Girardi, Richard C. Shelton

Psychosis Studies

Research output: Contribution to journal › Article › peer-review

224 Citations (Scopus)

Abstract

Recent studies have implicated brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression and the activity of antidepressant drugs. Serum BDNF levels are lower in depressed patients, and increase in response to antidepressant medication. However, how BDNF responds to different classes of antidepressant drugs is unknown. We assessed serum BDNF levels in 21 patients with major depressive episode treated with sertraline, escitalopram, or venlafaxine and 20 healthy controls. Serum samples were collected between 10 a.m. and 12 p.m. at baseline, 5 weeks, and 6 months of treatment. BDNF levels were measured via immunoassay. The severity of symptoms and response to treatment were assessed by the Hamilton rating scales for depression (HRSD). Baseline serum BDNF levels were significantly lower in depressed patients compared to controls. Sertraline increased BDNF levels after 5 weeks and 6 months of treatment. Venlafaxine increased BDNF levels only after 6 months. Escitalopram did not affect BDNF levels at either time point. A significant negative association was found between percentage increase in BDNF levels and percentage decreased in HRSD scores after 6 months of treatment. In conclusion, these results suggest that different antidepressant drugs have variable effects on serum BDNF levels. This is true even though the three different drugs were equally effective in relieving symptoms of depression and anxiety. (c) 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	247-254
Number of pages	8
Journal	Journal of Psychiatric Research
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/j.jpsychires.2008.03.014
Publication status	Published - Jan 2008

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Matrisciano, F., Bonaccorso, S., Ricciardi, A., Scaccianoce, S., Panaccione, I., Wang, L., Ruberto, A., Tatarelli, R., Nicoletti, F., Girardi, P., & Shelton, R. C. (2008). Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine. Journal of Psychiatric Research, 43(3), 247-254. https://doi.org/10.1016/j.jpsychires.2008.03.014

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title = "Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine",

abstract = "Recent studies have implicated brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression and the activity of antidepressant drugs. Serum BDNF levels are lower in depressed patients, and increase in response to antidepressant medication. However, how BDNF responds to different classes of antidepressant drugs is unknown. We assessed serum BDNF levels in 21 patients with major depressive episode treated with sertraline, escitalopram, or venlafaxine and 20 healthy controls. Serum samples were collected between 10 a.m. and 12 p.m. at baseline, 5 weeks, and 6 months of treatment. BDNF levels were measured via immunoassay. The severity of symptoms and response to treatment were assessed by the Hamilton rating scales for depression (HRSD). Baseline serum BDNF levels were significantly lower in depressed patients compared to controls. Sertraline increased BDNF levels after 5 weeks and 6 months of treatment. Venlafaxine increased BDNF levels only after 6 months. Escitalopram did not affect BDNF levels at either time point. A significant negative association was found between percentage increase in BDNF levels and percentage decreased in HRSD scores after 6 months of treatment. In conclusion, these results suggest that different antidepressant drugs have variable effects on serum BDNF levels. This is true even though the three different drugs were equally effective in relieving symptoms of depression and anxiety. (c) 2008 Elsevier Ltd. All rights reserved.",

author = "Francesco Matrisciano and Stefania Bonaccorso and Angelo Ricciardi and Sergio Scaccianoce and Isabella Panaccione and Lily Wang and Amedo Ruberto and Roberto Tatarelli and Ferdinando Nicoletti and Paolo Girardi and Shelton, {Richard C.}",

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Matrisciano, F, Bonaccorso, S, Ricciardi, A, Scaccianoce, S, Panaccione, I, Wang, L, Ruberto, A, Tatarelli, R, Nicoletti, F, Girardi, P & Shelton, RC 2008, 'Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine', Journal of Psychiatric Research, vol. 43, no. 3, pp. 247-254. https://doi.org/10.1016/j.jpsychires.2008.03.014

TY - JOUR

T1 - Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine

AU - Matrisciano, Francesco

AU - Bonaccorso, Stefania

AU - Ricciardi, Angelo

AU - Scaccianoce, Sergio

AU - Panaccione, Isabella

AU - Wang, Lily

AU - Ruberto, Amedo

AU - Tatarelli, Roberto

AU - Nicoletti, Ferdinando

AU - Girardi, Paolo

AU - Shelton, Richard C.

PY - 2008/1

Y1 - 2008/1

N2 - Recent studies have implicated brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression and the activity of antidepressant drugs. Serum BDNF levels are lower in depressed patients, and increase in response to antidepressant medication. However, how BDNF responds to different classes of antidepressant drugs is unknown. We assessed serum BDNF levels in 21 patients with major depressive episode treated with sertraline, escitalopram, or venlafaxine and 20 healthy controls. Serum samples were collected between 10 a.m. and 12 p.m. at baseline, 5 weeks, and 6 months of treatment. BDNF levels were measured via immunoassay. The severity of symptoms and response to treatment were assessed by the Hamilton rating scales for depression (HRSD). Baseline serum BDNF levels were significantly lower in depressed patients compared to controls. Sertraline increased BDNF levels after 5 weeks and 6 months of treatment. Venlafaxine increased BDNF levels only after 6 months. Escitalopram did not affect BDNF levels at either time point. A significant negative association was found between percentage increase in BDNF levels and percentage decreased in HRSD scores after 6 months of treatment. In conclusion, these results suggest that different antidepressant drugs have variable effects on serum BDNF levels. This is true even though the three different drugs were equally effective in relieving symptoms of depression and anxiety. (c) 2008 Elsevier Ltd. All rights reserved.

AB - Recent studies have implicated brain-derived neurotrophic factor (BDNF) in the pathophysiology of depression and the activity of antidepressant drugs. Serum BDNF levels are lower in depressed patients, and increase in response to antidepressant medication. However, how BDNF responds to different classes of antidepressant drugs is unknown. We assessed serum BDNF levels in 21 patients with major depressive episode treated with sertraline, escitalopram, or venlafaxine and 20 healthy controls. Serum samples were collected between 10 a.m. and 12 p.m. at baseline, 5 weeks, and 6 months of treatment. BDNF levels were measured via immunoassay. The severity of symptoms and response to treatment were assessed by the Hamilton rating scales for depression (HRSD). Baseline serum BDNF levels were significantly lower in depressed patients compared to controls. Sertraline increased BDNF levels after 5 weeks and 6 months of treatment. Venlafaxine increased BDNF levels only after 6 months. Escitalopram did not affect BDNF levels at either time point. A significant negative association was found between percentage increase in BDNF levels and percentage decreased in HRSD scores after 6 months of treatment. In conclusion, these results suggest that different antidepressant drugs have variable effects on serum BDNF levels. This is true even though the three different drugs were equally effective in relieving symptoms of depression and anxiety. (c) 2008 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.jpsychires.2008.03.014

DO - 10.1016/j.jpsychires.2008.03.014

M3 - Article

SN - 0022-3956

VL - 43

SP - 247

EP - 254

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

IS - 3

ER -

Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, escitalopram, or venlafaxine

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