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Changes in Default-Mode Network Associated With Childhood Trauma in Schizophrenia

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Changes in Default-Mode Network Associated With Childhood Trauma in Schizophrenia. / Dauvermann, Maria; Mothersill, David ; Rokita, Karolina I; King, Sinead; Holleran, Laurena; Kane, Ruán; McKernan, Declan; Kelly, John P; Morris, Derek W.; Corvin, Aiden; Hallahan, Brian; McDonald, C; Donohoe, Gary.

In: Schizophrenia Bulletin, Vol. 47, No. 5, 01.09.2021, p. 1482-1494.

Research output: Contribution to journalArticlepeer-review

Harvard

Dauvermann, M, Mothersill, D, Rokita, KI, King, S, Holleran, L, Kane, R, McKernan, D, Kelly, JP, Morris, DW, Corvin, A, Hallahan, B, McDonald, C & Donohoe, G 2021, 'Changes in Default-Mode Network Associated With Childhood Trauma in Schizophrenia', Schizophrenia Bulletin, vol. 47, no. 5, pp. 1482-1494. https://doi.org/10.1093/schbul/sbab025

APA

Dauvermann, M., Mothersill, D., Rokita, K. I., King, S., Holleran, L., Kane, R., McKernan, D., Kelly, J. P., Morris, D. W., Corvin, A., Hallahan, B., McDonald, C., & Donohoe, G. (2021). Changes in Default-Mode Network Associated With Childhood Trauma in Schizophrenia. Schizophrenia Bulletin, 47(5), 1482-1494. https://doi.org/10.1093/schbul/sbab025

Vancouver

Dauvermann M, Mothersill D, Rokita KI, King S, Holleran L, Kane R et al. Changes in Default-Mode Network Associated With Childhood Trauma in Schizophrenia. Schizophrenia Bulletin. 2021 Sep 1;47(5):1482-1494. https://doi.org/10.1093/schbul/sbab025

Author

Dauvermann, Maria ; Mothersill, David ; Rokita, Karolina I ; King, Sinead ; Holleran, Laurena ; Kane, Ruán ; McKernan, Declan ; Kelly, John P ; Morris, Derek W. ; Corvin, Aiden ; Hallahan, Brian ; McDonald, C ; Donohoe, Gary. / Changes in Default-Mode Network Associated With Childhood Trauma in Schizophrenia. In: Schizophrenia Bulletin. 2021 ; Vol. 47, No. 5. pp. 1482-1494.

Bibtex Download

@article{9af2f6be0ede497fb784e99eb6961cb5,
title = "Changes in Default-Mode Network Associated With Childhood Trauma in Schizophrenia",
abstract = "Background: There is considerable evidence of dysconnectivity within the default-mode network (DMN) in schizophrenia, as measured during resting-state functional MRI (rs-fMRI). History of childhood trauma (CT) is observed at a higher frequency in schizophrenia than in the general population, but its relationship to DMN functional connectivity has yet to be investigated.Methods: CT history and rs-fMRI data were collected in 65 individuals with schizophrenia and 132 healthy controls. Seed-based functional connectivity between each of 4 a priori defined seeds of the DMN (medial prefrontal cortex, right and left lateral parietal lobes, and the posterior cingulate cortex) and all other voxels of the brain were compared across groups. Effects of CT on functional connectivity were examined using multiple regression analyses. Where significant associations were observed, regression analyses were further used to determine whether variance in behavioral measures of Theory of Mind (ToM), previously associated with DMN recruitment, were explained by these associations.Results: Seed-based analyses revealed evidence of widespread reductions in functional connectivity in patients vs controls, including between the left/right parietal lobe (LP) and multiple other regions, including the parietal operculum bilaterally. Across all subjects, increased CT scores were associated with reduced prefrontal-parietal connectivity and, in patients, with increased prefrontal-cerebellar connectivity also. These CT-associated differences in DMN connectivity also predicted variation in behavioral measures of ToM.Conclusions: These findings suggest that CT history is associated with variation in DMN connectivity during rs-fMRI in patients with schizophrenia and healthy participants, which may partly mediate associations observed between early life adversity and cognitive performance.",
author = "Maria Dauvermann and David Mothersill and Rokita, {Karolina I} and Sinead King and Laurena Holleran and Ru{\'a}n Kane and Declan McKernan and Kelly, {John P} and Morris, {Derek W.} and Aiden Corvin and Brian Hallahan and C McDonald and Gary Donohoe",
note = "Funding Information: This work was funded by grants to G.D. from the European Research Council (ERC-2015-STG-677467) and Science Foundation Ireland (SFI-16/ERCS/3787). Publisher Copyright: {\textcopyright} The Author(s) 2021. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = sep,
day = "1",
doi = "10.1093/schbul/sbab025",
language = "English",
volume = "47",
pages = "1482--1494",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "5",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Changes in Default-Mode Network Associated With Childhood Trauma in Schizophrenia

AU - Dauvermann, Maria

AU - Mothersill, David

AU - Rokita, Karolina I

AU - King, Sinead

AU - Holleran, Laurena

AU - Kane, Ruán

AU - McKernan, Declan

AU - Kelly, John P

AU - Morris, Derek W.

AU - Corvin, Aiden

AU - Hallahan, Brian

AU - McDonald, C

AU - Donohoe, Gary

N1 - Funding Information: This work was funded by grants to G.D. from the European Research Council (ERC-2015-STG-677467) and Science Foundation Ireland (SFI-16/ERCS/3787). Publisher Copyright: © The Author(s) 2021. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Background: There is considerable evidence of dysconnectivity within the default-mode network (DMN) in schizophrenia, as measured during resting-state functional MRI (rs-fMRI). History of childhood trauma (CT) is observed at a higher frequency in schizophrenia than in the general population, but its relationship to DMN functional connectivity has yet to be investigated.Methods: CT history and rs-fMRI data were collected in 65 individuals with schizophrenia and 132 healthy controls. Seed-based functional connectivity between each of 4 a priori defined seeds of the DMN (medial prefrontal cortex, right and left lateral parietal lobes, and the posterior cingulate cortex) and all other voxels of the brain were compared across groups. Effects of CT on functional connectivity were examined using multiple regression analyses. Where significant associations were observed, regression analyses were further used to determine whether variance in behavioral measures of Theory of Mind (ToM), previously associated with DMN recruitment, were explained by these associations.Results: Seed-based analyses revealed evidence of widespread reductions in functional connectivity in patients vs controls, including between the left/right parietal lobe (LP) and multiple other regions, including the parietal operculum bilaterally. Across all subjects, increased CT scores were associated with reduced prefrontal-parietal connectivity and, in patients, with increased prefrontal-cerebellar connectivity also. These CT-associated differences in DMN connectivity also predicted variation in behavioral measures of ToM.Conclusions: These findings suggest that CT history is associated with variation in DMN connectivity during rs-fMRI in patients with schizophrenia and healthy participants, which may partly mediate associations observed between early life adversity and cognitive performance.

AB - Background: There is considerable evidence of dysconnectivity within the default-mode network (DMN) in schizophrenia, as measured during resting-state functional MRI (rs-fMRI). History of childhood trauma (CT) is observed at a higher frequency in schizophrenia than in the general population, but its relationship to DMN functional connectivity has yet to be investigated.Methods: CT history and rs-fMRI data were collected in 65 individuals with schizophrenia and 132 healthy controls. Seed-based functional connectivity between each of 4 a priori defined seeds of the DMN (medial prefrontal cortex, right and left lateral parietal lobes, and the posterior cingulate cortex) and all other voxels of the brain were compared across groups. Effects of CT on functional connectivity were examined using multiple regression analyses. Where significant associations were observed, regression analyses were further used to determine whether variance in behavioral measures of Theory of Mind (ToM), previously associated with DMN recruitment, were explained by these associations.Results: Seed-based analyses revealed evidence of widespread reductions in functional connectivity in patients vs controls, including between the left/right parietal lobe (LP) and multiple other regions, including the parietal operculum bilaterally. Across all subjects, increased CT scores were associated with reduced prefrontal-parietal connectivity and, in patients, with increased prefrontal-cerebellar connectivity also. These CT-associated differences in DMN connectivity also predicted variation in behavioral measures of ToM.Conclusions: These findings suggest that CT history is associated with variation in DMN connectivity during rs-fMRI in patients with schizophrenia and healthy participants, which may partly mediate associations observed between early life adversity and cognitive performance.

UR - http://www.scopus.com/inward/record.url?scp=85114608951&partnerID=8YFLogxK

U2 - 10.1093/schbul/sbab025

DO - 10.1093/schbul/sbab025

M3 - Article

VL - 47

SP - 1482

EP - 1494

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 5

ER -

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