Changes in functional imaging parameters following induction chemotherapy have important implications for individualised patient-based treatment regimens for advanced head and neck cancer

Ceri Powell; M Schmidt; M Borri; Dow-Mu Koh; Mike Partridge; Angela Riddell; Gary Cook; SA Bhide; Chris Nutting; Kevin Harrington; Kate Newbold

doi:10.1016/j.radonc.2012.09.009

Changes in functional imaging parameters following induction chemotherapy have important implications for individualised patient-based treatment regimens for advanced head and neck cancer

Ceri Powell, M Schmidt, M Borri, Dow-Mu Koh, Mike Partridge, Angela Riddell, Gary Cook, SA Bhide, Chris Nutting, Kevin Harrington, Kate Newbold

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Background
When induction chemotherapy (IC) is used prior to chemoradiotherapy (CRT) in head and neck cancer (HNC), functional imaging (FI) may inform adaptation of treatment plans with the aim of optimising outcomes. Understanding the impact of IC on FI parameters is, therefore, essential.

Purpose
To prospectively evaluate the feasibility of acquiring serial FI (18F-FDG-PET, diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI) and its role in defining individualised treatment regimens following IC in HNC.

Methods and materials
Ten patients with stage III and IV HNC underwent conventional (CT and MRI) and functional (DW, DCE-MRI and 18F-FDG-PET/CT) imaging at baseline and following two cycles of IC prior to definitive CRT.

Results
One patient withdrew due to claustrophobia. Seven out of nine patients had a complete metabolic response to IC on 18F-FDG-PET imaging. DCE-MRI showed a significant fall in transfer constant (Ktrans) (0.209 vs 0.129 min−1P < 0.01) and integrated area under gadolinium curve at 60 s (IAUGC6O) (18.4 vs 11.9 mmol/min, P < 0.01) and DW-MRI a rise in ADC (0.89 vs 1.06 × 10−3 mm2/s, P < 0.01) following IC.

Conclusions
Acquiring FI sequences is feasible in HNC. There are marked changes in FI parameters following IC which may guide adaptation of individualised treatment regimens.

Original language	English
Article number	N/A
Pages (from-to)	112-117
Number of pages	6
Journal	Radiotherapy and Oncology
Volume	106
Issue number	1
DOIs	https://doi.org/10.1016/j.radonc.2012.09.009
Publication status	Published - 1 Jan 2013

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10.1016/j.radonc.2012.09.009

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Powell, C., Schmidt, M., Borri, M., Koh, D.-M., Partridge, M., Riddell, A., Cook, G., Bhide, SA., Nutting, C., Harrington, K., & Newbold, K. (2013). Changes in functional imaging parameters following induction chemotherapy have important implications for individualised patient-based treatment regimens for advanced head and neck cancer. Radiotherapy and Oncology, 106(1), 112-117. Article N/A. https://doi.org/10.1016/j.radonc.2012.09.009

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title = "Changes in functional imaging parameters following induction chemotherapy have important implications for individualised patient-based treatment regimens for advanced head and neck cancer",

abstract = "BackgroundWhen induction chemotherapy (IC) is used prior to chemoradiotherapy (CRT) in head and neck cancer (HNC), functional imaging (FI) may inform adaptation of treatment plans with the aim of optimising outcomes. Understanding the impact of IC on FI parameters is, therefore, essential.PurposeTo prospectively evaluate the feasibility of acquiring serial FI (18F-FDG-PET, diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI) and its role in defining individualised treatment regimens following IC in HNC.Methods and materialsTen patients with stage III and IV HNC underwent conventional (CT and MRI) and functional (DW, DCE-MRI and 18F-FDG-PET/CT) imaging at baseline and following two cycles of IC prior to definitive CRT.ResultsOne patient withdrew due to claustrophobia. Seven out of nine patients had a complete metabolic response to IC on 18F-FDG-PET imaging. DCE-MRI showed a significant fall in transfer constant (Ktrans) (0.209 vs 0.129 min−1P < 0.01) and integrated area under gadolinium curve at 60 s (IAUGC6O) (18.4 vs 11.9 mmol/min, P < 0.01) and DW-MRI a rise in ADC (0.89 vs 1.06 × 10−3 mm2/s, P < 0.01) following IC.ConclusionsAcquiring FI sequences is feasible in HNC. There are marked changes in FI parameters following IC which may guide adaptation of individualised treatment regimens.",

author = "Ceri Powell and M Schmidt and M Borri and Dow-Mu Koh and Mike Partridge and Angela Riddell and Gary Cook and SA Bhide and Chris Nutting and Kevin Harrington and Kate Newbold",

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doi = "10.1016/j.radonc.2012.09.009",

language = "English",

volume = "106",

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Powell, C, Schmidt, M, Borri, M, Koh, D-M, Partridge, M, Riddell, A, Cook, G, Bhide, SA, Nutting, C, Harrington, K & Newbold, K 2013, 'Changes in functional imaging parameters following induction chemotherapy have important implications for individualised patient-based treatment regimens for advanced head and neck cancer', Radiotherapy and Oncology, vol. 106, no. 1, N/A, pp. 112-117. https://doi.org/10.1016/j.radonc.2012.09.009

Changes in functional imaging parameters following induction chemotherapy have important implications for individualised patient-based treatment regimens for advanced head and neck cancer. / Powell, Ceri; Schmidt, M; Borri, M et al.
In: Radiotherapy and Oncology, Vol. 106, No. 1, N/A, 01.01.2013, p. 112-117.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Changes in functional imaging parameters following induction chemotherapy have important implications for individualised patient-based treatment regimens for advanced head and neck cancer

AU - Powell, Ceri

AU - Schmidt, M

AU - Borri, M

AU - Koh, Dow-Mu

AU - Partridge, Mike

AU - Riddell, Angela

AU - Cook, Gary

AU - Bhide, SA

AU - Nutting, Chris

AU - Harrington, Kevin

AU - Newbold, Kate

PY - 2013/1/1

Y1 - 2013/1/1

N2 - BackgroundWhen induction chemotherapy (IC) is used prior to chemoradiotherapy (CRT) in head and neck cancer (HNC), functional imaging (FI) may inform adaptation of treatment plans with the aim of optimising outcomes. Understanding the impact of IC on FI parameters is, therefore, essential.PurposeTo prospectively evaluate the feasibility of acquiring serial FI (18F-FDG-PET, diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI) and its role in defining individualised treatment regimens following IC in HNC.Methods and materialsTen patients with stage III and IV HNC underwent conventional (CT and MRI) and functional (DW, DCE-MRI and 18F-FDG-PET/CT) imaging at baseline and following two cycles of IC prior to definitive CRT.ResultsOne patient withdrew due to claustrophobia. Seven out of nine patients had a complete metabolic response to IC on 18F-FDG-PET imaging. DCE-MRI showed a significant fall in transfer constant (Ktrans) (0.209 vs 0.129 min−1P < 0.01) and integrated area under gadolinium curve at 60 s (IAUGC6O) (18.4 vs 11.9 mmol/min, P < 0.01) and DW-MRI a rise in ADC (0.89 vs 1.06 × 10−3 mm2/s, P < 0.01) following IC.ConclusionsAcquiring FI sequences is feasible in HNC. There are marked changes in FI parameters following IC which may guide adaptation of individualised treatment regimens.

AB - BackgroundWhen induction chemotherapy (IC) is used prior to chemoradiotherapy (CRT) in head and neck cancer (HNC), functional imaging (FI) may inform adaptation of treatment plans with the aim of optimising outcomes. Understanding the impact of IC on FI parameters is, therefore, essential.PurposeTo prospectively evaluate the feasibility of acquiring serial FI (18F-FDG-PET, diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI) and its role in defining individualised treatment regimens following IC in HNC.Methods and materialsTen patients with stage III and IV HNC underwent conventional (CT and MRI) and functional (DW, DCE-MRI and 18F-FDG-PET/CT) imaging at baseline and following two cycles of IC prior to definitive CRT.ResultsOne patient withdrew due to claustrophobia. Seven out of nine patients had a complete metabolic response to IC on 18F-FDG-PET imaging. DCE-MRI showed a significant fall in transfer constant (Ktrans) (0.209 vs 0.129 min−1P < 0.01) and integrated area under gadolinium curve at 60 s (IAUGC6O) (18.4 vs 11.9 mmol/min, P < 0.01) and DW-MRI a rise in ADC (0.89 vs 1.06 × 10−3 mm2/s, P < 0.01) following IC.ConclusionsAcquiring FI sequences is feasible in HNC. There are marked changes in FI parameters following IC which may guide adaptation of individualised treatment regimens.

U2 - 10.1016/j.radonc.2012.09.009

DO - 10.1016/j.radonc.2012.09.009

M3 - Article

SN - 0167-8140

VL - 106

SP - 112

EP - 117

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 1

M1 - N/A

ER -

Changes in functional imaging parameters following induction chemotherapy have important implications for individualised patient-based treatment regimens for advanced head and neck cancer

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