CHAPTER 8. Chelators for Diagnostic Molecular Imaging with Radioisotopes of Copper, Gallium and Zirconium

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Abstract

The radiometallic isotopes 64Cu, 68Ga and 89Zr have immense utility in molecular PET imaging. The ability to prepare clinically useful 64Cu, 68Ga and 89Zr radiopharmaceuticals is contingent on efficient chelators that enable access to simple radiolabelling methodologies, as well as providing metal complexes that are highly stable in vivo. This review highlights how the different design requirements for 64Cu2+, 68Ga3+ and 89Zr4+ chelators are dictated by not only each specific metal ion’s coordination preferences, but also the radionuclide’s half-life, the biomolecular vehicle to which the complex is attached, and the molecular process being targeted
Original languageEnglish
Title of host publicationMetal Chelation in Medicine
EditorsRobert R Crichton, Roberta J Ward, Robert C Hider
PublisherRoyal Society of Chemistry
Pages260-312
ISBN (Print)978-1-78262-064-8
DOIs
Publication statusPublished - 2017

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