Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins

Anthea J. Tennant-Eyles; Hilary Moffitt; Caroline A. Whitehouse; Roland G. Roberts

doi:10.1016/j.bbrc.2011.02.076

Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins

Anthea J. Tennant-Eyles, Hilary Moffitt, Caroline A. Whitehouse, Roland G. Roberts

Medical & Molecular Genetics

King's College London

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The FAM69 family of cysteine-rich type II transmembrane proteins comprises three members in all vertebrates except fish, and orthologues with a conserved structure are present throughout metazoa. All three murine FAM69 proteins (FAM69A, FAM69B, FAM69C) localise to the endoplasmic reticulum (ER) in cultured cells, probably via N-terminal di-arginine motifs. Mammalian FAM69A is ubiquitously expressed, FAM69B is strongly expressed in the brain and in peripheral endothelial cells, and FAM69C in the brain and eye. Antibodies against mouse FAM69B strongly stain the ER of a subset of neurons in the brain. FAM69 proteins are likely to play a fundamental and highly conserved role in the ER of most metazoan cells, with additional specialised roles in the vertebrate nervous system. (C) 2011 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	471 - 477
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	406
Issue number	3
DOIs	https://doi.org/10.1016/j.bbrc.2011.02.076
Publication status	Published - 18 Mar 2011

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abstract = "The FAM69 family of cysteine-rich type II transmembrane proteins comprises three members in all vertebrates except fish, and orthologues with a conserved structure are present throughout metazoa. All three murine FAM69 proteins (FAM69A, FAM69B, FAM69C) localise to the endoplasmic reticulum (ER) in cultured cells, probably via N-terminal di-arginine motifs. Mammalian FAM69A is ubiquitously expressed, FAM69B is strongly expressed in the brain and in peripheral endothelial cells, and FAM69C in the brain and eye. Antibodies against mouse FAM69B strongly stain the ER of a subset of neurons in the brain. FAM69 proteins are likely to play a fundamental and highly conserved role in the ER of most metazoan cells, with additional specialised roles in the vertebrate nervous system. (C) 2011 Elsevier Inc. All rights reserved.",

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T1 - Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins

AU - Tennant-Eyles, Anthea J.

AU - Moffitt, Hilary

AU - Whitehouse, Caroline A.

AU - Roberts, Roland G.

PY - 2011/3/18

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AB - The FAM69 family of cysteine-rich type II transmembrane proteins comprises three members in all vertebrates except fish, and orthologues with a conserved structure are present throughout metazoa. All three murine FAM69 proteins (FAM69A, FAM69B, FAM69C) localise to the endoplasmic reticulum (ER) in cultured cells, probably via N-terminal di-arginine motifs. Mammalian FAM69A is ubiquitously expressed, FAM69B is strongly expressed in the brain and in peripheral endothelial cells, and FAM69C in the brain and eye. Antibodies against mouse FAM69B strongly stain the ER of a subset of neurons in the brain. FAM69 proteins are likely to play a fundamental and highly conserved role in the ER of most metazoan cells, with additional specialised roles in the vertebrate nervous system. (C) 2011 Elsevier Inc. All rights reserved.

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DO - 10.1016/j.bbrc.2011.02.076

M3 - Article

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SP - 471

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

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Characterisation of the FAM69 family of cysteine-rich endoplasmic reticulum proteins

Abstract

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