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Characterising the Provision of SeHCAT Services in the United Kingdom: A Multi-Centre Prospective Survey

Research output: Chapter in Book/Report/Conference proceedingMeeting abstract

Original languageEnglish
Title of host publicationNordic-Baltic Biometric Conference (NBBC15)
Publication statusUnpublished - 2015
Event5th Nordic-Baltic Biometric Conference - Iceland, Reykjavik, Iceland
Duration: 8 Jun 201510 Jun 2015


Conference5th Nordic-Baltic Biometric Conference

King's Authors


Background: Bile Acid Malabsorption (BAM) is a cause of many diarrhoeal conditions. However, robust data on the prevalence of BAM does not exist in the United Kingdom (UK). A clinical diagnosis of BAM can be confirmed using SeHCAT (tauroselcholic [75selenium] acid), a radiolabelled synthetic bile acid. SeHCAT retention levels are assessed at two time points, and used to determine a BAM diagnosis, leading to potential treatment with bile acid sequestrants (BAS).

Objective: A prospective survey was conducted to characterise day-to-day practice associated with clinical indications for referring patients for a SeHCAT test.

Methods: Eligible data from 38 UK centres and 1,036 patients were entered into a validated management system. Patients in the survey had a mean age of 50 years (range 6 -89 years), were predominantly female (65%) and the majority were listed as being white (77%).

Results: The mean SeHCAT retention score for patients was 19%. However, this differed with suspected BAM type: Type 1 (9%), Type 2 (21%) and Type 3 (22%). A BAS prescription was not given to 27% of patients with a centre-defined ‘abnormal’ SeHCAT retention result.

The SeHCAT protocol varied between centres, for example, there was no standardised patient positioning, and a wide range of additional and alternative treatments post-SeHCAT were documented.

Conclusion: The survey characterized the variability in provision of SeHCAT, patient clinical history, post-SeHCAT care pathway and SeHCAT results. One of the most notable findings is the clear disparity in provision of both SeHCAT and BAS prescription across practices and amongst patients themselves.

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