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Characteristics and circumstances of heroin and pharmaceutical opioid overdose deaths: Comparison across opioids

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Characteristics and circumstances of heroin and pharmaceutical opioid overdose deaths : Comparison across opioids. / Roxburgh, Amanda; Hall, Wayne D.; Gisev, Natasa; Degenhardt, Louisa.

In: Drug and alcohol dependence, Vol. 205, 107533, 01.12.2019.

Research output: Contribution to journalArticle

Harvard

Roxburgh, A, Hall, WD, Gisev, N & Degenhardt, L 2019, 'Characteristics and circumstances of heroin and pharmaceutical opioid overdose deaths: Comparison across opioids', Drug and alcohol dependence, vol. 205, 107533. https://doi.org/10.1016/j.drugalcdep.2019.06.035

APA

Roxburgh, A., Hall, W. D., Gisev, N., & Degenhardt, L. (2019). Characteristics and circumstances of heroin and pharmaceutical opioid overdose deaths: Comparison across opioids. Drug and alcohol dependence, 205, [107533]. https://doi.org/10.1016/j.drugalcdep.2019.06.035

Vancouver

Roxburgh A, Hall WD, Gisev N, Degenhardt L. Characteristics and circumstances of heroin and pharmaceutical opioid overdose deaths: Comparison across opioids. Drug and alcohol dependence. 2019 Dec 1;205. 107533. https://doi.org/10.1016/j.drugalcdep.2019.06.035

Author

Roxburgh, Amanda ; Hall, Wayne D. ; Gisev, Natasa ; Degenhardt, Louisa. / Characteristics and circumstances of heroin and pharmaceutical opioid overdose deaths : Comparison across opioids. In: Drug and alcohol dependence. 2019 ; Vol. 205.

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@article{9c276c5bf2bc46b08918b3bc95db8e8f,
title = "Characteristics and circumstances of heroin and pharmaceutical opioid overdose deaths: Comparison across opioids",
abstract = "Background: Although much is known about the correlates of heroin overdose, less is known about pharmaceutical opioid (PO) overdose. This study aimed to examine correlates of opioid overdose deaths by opioid and compare correlates between opioids. Methods: Analysis of opioid overdose deaths in Australia between 2000–2015, extracted from the National Coronial Information System (NCIS). The NCIS is an online database of deaths reportable to the coroner, and contains coroner's findings, autopsy and toxicology reports. Deaths were categorized into mutually exclusive groups: 1) Heroin deaths; and 2) PO deaths (excluding heroin). PO deaths were examined by individual opioid. Results: There were 10,795 opioid overdose deaths over the study period. Relative to deaths occurring in major cities, deaths in regional/remote areas had 15.2 (95 {\%} CI: 11.5–20.2) times the risk of being attributed to pharmaceutical fentanyl than heroin. Relative to deaths among people without a recorded history of chronic pain, deaths among people with a recorded history of chronic pain had a 1.9–10.7-fold increased risk of the death being attributed to POs than heroin. Deaths among people with a recorded history of substance use problems where the opioid was injected prior to death had 7.2 and 1.7 times the risk of being attributed to methadone and pharmaceutical fentanyl (respectively) than heroin. Conclusions: Findings suggest the need to: educate PO consumers about the risks of overdose at the time of prescribing; increase coverage and engagement in opioid dependence treatment (particularly in regional/remote areas); and increase uptake of take-home naloxone to reduce opioid overdose mortality.",
keywords = "Fentanyl, Heroin, Morphine, Mortality, Opioid analgesics, Opioid overdose deaths, Oxycodone, Prescription opioids",
author = "Amanda Roxburgh and Hall, {Wayne D.} and Natasa Gisev and Louisa Degenhardt",
year = "2019",
month = "12",
day = "1",
doi = "10.1016/j.drugalcdep.2019.06.035",
language = "English",
volume = "205",
journal = "Drug and alcohol dependence",
issn = "0376-8716",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Characteristics and circumstances of heroin and pharmaceutical opioid overdose deaths

T2 - Comparison across opioids

AU - Roxburgh, Amanda

AU - Hall, Wayne D.

AU - Gisev, Natasa

AU - Degenhardt, Louisa

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Background: Although much is known about the correlates of heroin overdose, less is known about pharmaceutical opioid (PO) overdose. This study aimed to examine correlates of opioid overdose deaths by opioid and compare correlates between opioids. Methods: Analysis of opioid overdose deaths in Australia between 2000–2015, extracted from the National Coronial Information System (NCIS). The NCIS is an online database of deaths reportable to the coroner, and contains coroner's findings, autopsy and toxicology reports. Deaths were categorized into mutually exclusive groups: 1) Heroin deaths; and 2) PO deaths (excluding heroin). PO deaths were examined by individual opioid. Results: There were 10,795 opioid overdose deaths over the study period. Relative to deaths occurring in major cities, deaths in regional/remote areas had 15.2 (95 % CI: 11.5–20.2) times the risk of being attributed to pharmaceutical fentanyl than heroin. Relative to deaths among people without a recorded history of chronic pain, deaths among people with a recorded history of chronic pain had a 1.9–10.7-fold increased risk of the death being attributed to POs than heroin. Deaths among people with a recorded history of substance use problems where the opioid was injected prior to death had 7.2 and 1.7 times the risk of being attributed to methadone and pharmaceutical fentanyl (respectively) than heroin. Conclusions: Findings suggest the need to: educate PO consumers about the risks of overdose at the time of prescribing; increase coverage and engagement in opioid dependence treatment (particularly in regional/remote areas); and increase uptake of take-home naloxone to reduce opioid overdose mortality.

AB - Background: Although much is known about the correlates of heroin overdose, less is known about pharmaceutical opioid (PO) overdose. This study aimed to examine correlates of opioid overdose deaths by opioid and compare correlates between opioids. Methods: Analysis of opioid overdose deaths in Australia between 2000–2015, extracted from the National Coronial Information System (NCIS). The NCIS is an online database of deaths reportable to the coroner, and contains coroner's findings, autopsy and toxicology reports. Deaths were categorized into mutually exclusive groups: 1) Heroin deaths; and 2) PO deaths (excluding heroin). PO deaths were examined by individual opioid. Results: There were 10,795 opioid overdose deaths over the study period. Relative to deaths occurring in major cities, deaths in regional/remote areas had 15.2 (95 % CI: 11.5–20.2) times the risk of being attributed to pharmaceutical fentanyl than heroin. Relative to deaths among people without a recorded history of chronic pain, deaths among people with a recorded history of chronic pain had a 1.9–10.7-fold increased risk of the death being attributed to POs than heroin. Deaths among people with a recorded history of substance use problems where the opioid was injected prior to death had 7.2 and 1.7 times the risk of being attributed to methadone and pharmaceutical fentanyl (respectively) than heroin. Conclusions: Findings suggest the need to: educate PO consumers about the risks of overdose at the time of prescribing; increase coverage and engagement in opioid dependence treatment (particularly in regional/remote areas); and increase uptake of take-home naloxone to reduce opioid overdose mortality.

KW - Fentanyl

KW - Heroin

KW - Morphine

KW - Mortality

KW - Opioid analgesics

KW - Opioid overdose deaths

KW - Oxycodone

KW - Prescription opioids

UR - http://www.scopus.com/inward/record.url?scp=85074349334&partnerID=8YFLogxK

U2 - 10.1016/j.drugalcdep.2019.06.035

DO - 10.1016/j.drugalcdep.2019.06.035

M3 - Article

C2 - 31704378

AN - SCOPUS:85074349334

VL - 205

JO - Drug and alcohol dependence

JF - Drug and alcohol dependence

SN - 0376-8716

M1 - 107533

ER -

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