Characterization of rapid cycling bipolar patients presenting with major depressive episode within the BRIDGE-II-MIX study

for the BRIDGE-II-Mix Study Group

doi:10.1111/bdi.12994

Characterization of rapid cycling bipolar patients presenting with major depressive episode within the BRIDGE-II-MIX study

for the BRIDGE-II-Mix Study Group

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Objectives: The “Bipolar Disorders: Improving Diagnosis, Guidance, and Education” (BRIDGE-II-Mix) study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions and to compare their clinical validity, looking into specific features such as rapid cycling (RC). Methods: Psychiatric symptoms, socio-demographic, and clinical variables were collected from a sample of 2811 MDE patients, of which 726 (25.8%) were diagnosed with bipolar disorder (BD). The characteristics of bipolar patients with RC (BD-RC) and without (BD-NRC) RC were compared. Results: Of 726 BD patients, 159 (21.9%) met DSM-5 criteria for RC. BD-RC group presented a higher number of lifetime depressive episodes (p < 0.001) with shorter duration of depressive episodes, and more psychiatric comorbidities, as well as higher rates of atypical features (p = 0.016) and concomitant (hypo)manic symptoms (irritable mood (p = 0.001); risky behavior (p = 0.005); impulsivity (p = 0.006); and psychomotor agitation (p = 0.029)). Patients with RC had a worse functioning (p = 0.033), more obesity (p = 0.003), and were significantly more likely to be treated with three or more drugs (p = 0.007). Conclusions: Important clinical differences between bipolar patients with and without a RC include more depressive morbidity, higher incidence of anxiety disorders, addiction, bulimia, and borderline personality disorder, as well as atypical features during depression and symptoms such as irritability, risky behavior, impulsivity, and agitation. RC patients had poorer functioning than patients without RC, more obesity, and had to be treated with more drugs.

Original language	English
Pages (from-to)	391-399
Number of pages	9
Journal	Bipolar Disorders
Volume	23
Issue number	4
DOIs	https://doi.org/10.1111/bdi.12994
Publication status	Published - Jun 2021

Keywords

bipolar disorder
clinical characteristics
rapid cycling

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/bdi.12994

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@article{96b7dabf11104bdc967f1ab81346f023,

title = "Characterization of rapid cycling bipolar patients presenting with major depressive episode within the BRIDGE-II-MIX study",

abstract = "Objectives: The “Bipolar Disorders: Improving Diagnosis, Guidance, and Education” (BRIDGE-II-Mix) study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions and to compare their clinical validity, looking into specific features such as rapid cycling (RC). Methods: Psychiatric symptoms, socio-demographic, and clinical variables were collected from a sample of 2811 MDE patients, of which 726 (25.8%) were diagnosed with bipolar disorder (BD). The characteristics of bipolar patients with RC (BD-RC) and without (BD-NRC) RC were compared. Results: Of 726 BD patients, 159 (21.9%) met DSM-5 criteria for RC. BD-RC group presented a higher number of lifetime depressive episodes (p < 0.001) with shorter duration of depressive episodes, and more psychiatric comorbidities, as well as higher rates of atypical features (p = 0.016) and concomitant (hypo)manic symptoms (irritable mood (p = 0.001); risky behavior (p = 0.005); impulsivity (p = 0.006); and psychomotor agitation (p = 0.029)). Patients with RC had a worse functioning (p = 0.033), more obesity (p = 0.003), and were significantly more likely to be treated with three or more drugs (p = 0.007). Conclusions: Important clinical differences between bipolar patients with and without a RC include more depressive morbidity, higher incidence of anxiety disorders, addiction, bulimia, and borderline personality disorder, as well as atypical features during depression and symptoms such as irritability, risky behavior, impulsivity, and agitation. RC patients had poorer functioning than patients without RC, more obesity, and had to be treated with more drugs.",

keywords = "bipolar disorder, clinical characteristics, rapid cycling",

author = "{for the BRIDGE-II-Mix Study Group} and {Antonietta Furio}, Maria and Dina Popovic and Eduard Vieta and Yelena Stukalin and Michal Hagin and Carla Torrent and Azorin, {Jean Michel} and Jules Angst and Bowden, {Charles L.} and Sergey Mosolov and Young, {Allan H.} and Giulio Perugi",

year = "2021",

month = jun,

doi = "10.1111/bdi.12994",

language = "English",

volume = "23",

pages = "391--399",

journal = "Bipolar Disorders",

issn = "1398-5647",

publisher = "Blackwell Munksgaard",

number = "4",

}

TY - JOUR

T1 - Characterization of rapid cycling bipolar patients presenting with major depressive episode within the BRIDGE-II-MIX study

AU - for the BRIDGE-II-Mix Study Group

AU - Antonietta Furio, Maria

AU - Popovic, Dina

AU - Vieta, Eduard

AU - Stukalin, Yelena

AU - Hagin, Michal

AU - Torrent, Carla

AU - Azorin, Jean Michel

AU - Angst, Jules

AU - Bowden, Charles L.

AU - Mosolov, Sergey

AU - Young, Allan H.

AU - Perugi, Giulio

PY - 2021/6

Y1 - 2021/6

N2 - Objectives: The “Bipolar Disorders: Improving Diagnosis, Guidance, and Education” (BRIDGE-II-Mix) study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions and to compare their clinical validity, looking into specific features such as rapid cycling (RC). Methods: Psychiatric symptoms, socio-demographic, and clinical variables were collected from a sample of 2811 MDE patients, of which 726 (25.8%) were diagnosed with bipolar disorder (BD). The characteristics of bipolar patients with RC (BD-RC) and without (BD-NRC) RC were compared. Results: Of 726 BD patients, 159 (21.9%) met DSM-5 criteria for RC. BD-RC group presented a higher number of lifetime depressive episodes (p < 0.001) with shorter duration of depressive episodes, and more psychiatric comorbidities, as well as higher rates of atypical features (p = 0.016) and concomitant (hypo)manic symptoms (irritable mood (p = 0.001); risky behavior (p = 0.005); impulsivity (p = 0.006); and psychomotor agitation (p = 0.029)). Patients with RC had a worse functioning (p = 0.033), more obesity (p = 0.003), and were significantly more likely to be treated with three or more drugs (p = 0.007). Conclusions: Important clinical differences between bipolar patients with and without a RC include more depressive morbidity, higher incidence of anxiety disorders, addiction, bulimia, and borderline personality disorder, as well as atypical features during depression and symptoms such as irritability, risky behavior, impulsivity, and agitation. RC patients had poorer functioning than patients without RC, more obesity, and had to be treated with more drugs.

AB - Objectives: The “Bipolar Disorders: Improving Diagnosis, Guidance, and Education” (BRIDGE-II-Mix) study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions and to compare their clinical validity, looking into specific features such as rapid cycling (RC). Methods: Psychiatric symptoms, socio-demographic, and clinical variables were collected from a sample of 2811 MDE patients, of which 726 (25.8%) were diagnosed with bipolar disorder (BD). The characteristics of bipolar patients with RC (BD-RC) and without (BD-NRC) RC were compared. Results: Of 726 BD patients, 159 (21.9%) met DSM-5 criteria for RC. BD-RC group presented a higher number of lifetime depressive episodes (p < 0.001) with shorter duration of depressive episodes, and more psychiatric comorbidities, as well as higher rates of atypical features (p = 0.016) and concomitant (hypo)manic symptoms (irritable mood (p = 0.001); risky behavior (p = 0.005); impulsivity (p = 0.006); and psychomotor agitation (p = 0.029)). Patients with RC had a worse functioning (p = 0.033), more obesity (p = 0.003), and were significantly more likely to be treated with three or more drugs (p = 0.007). Conclusions: Important clinical differences between bipolar patients with and without a RC include more depressive morbidity, higher incidence of anxiety disorders, addiction, bulimia, and borderline personality disorder, as well as atypical features during depression and symptoms such as irritability, risky behavior, impulsivity, and agitation. RC patients had poorer functioning than patients without RC, more obesity, and had to be treated with more drugs.

KW - bipolar disorder

KW - clinical characteristics

KW - rapid cycling

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U2 - 10.1111/bdi.12994

DO - 10.1111/bdi.12994

M3 - Article

C2 - 32959482

AN - SCOPUS:85092244583

SN - 1398-5647

VL - 23

SP - 391

EP - 399

JO - Bipolar Disorders

JF - Bipolar Disorders

IS - 4

ER -

Characterization of rapid cycling bipolar patients presenting with major depressive episode within the BRIDGE-II-MIX study

Abstract

Keywords

UN SDGs

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