Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve

TY - JOUR

T1 - Characterization of the anandamide induced depolarization of guinea-pig isolated vagus nerve

AU - Kagaya, M

AU - Lamb, J

AU - Robbins, J

AU - Page, C P

AU - Spina, D

PY - 2002/9

Y1 - 2002/9

N2 - 1 There is considerable interest in elucidating potential endogenously derived agonists of the vanilloid receptor and the role of anandamide in this regard has received considerable attention. In the present study, we have used an electrophysiological technique to investigate the mechanism of activation of vanilloid receptors in an isolated vagal preparation. 2 Both capsaicin and anandamide depolarized de-sheathed whole vagal nerve preparations that was antagonized by the VR1 antagonist, capsazepine (P

AB - 1 There is considerable interest in elucidating potential endogenously derived agonists of the vanilloid receptor and the role of anandamide in this regard has received considerable attention. In the present study, we have used an electrophysiological technique to investigate the mechanism of activation of vanilloid receptors in an isolated vagal preparation. 2 Both capsaicin and anandamide depolarized de-sheathed whole vagal nerve preparations that was antagonized by the VR1 antagonist, capsazepine (P

UR - http://www.scopus.com/inward/record.url?scp=0036729532&partnerID=8YFLogxK

U2 - 10.1038/sj.bjp.0704840

DO - 10.1038/sj.bjp.0704840

M3 - Article

SN - 1476-5381

VL - 137

SP - 39

EP - 48

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 1

ER -