TY - JOUR
T1 - Characterizing anhedonia
T2 - A systematic review of neuroimaging across the subtypes of reward processing deficits in depression
AU - Borsini, Alessandra
AU - Wallis, Amelia St John
AU - Zunszain, Patricia
AU - Pariante, Carmine Maria
AU - Kempton, Matthew J.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Anhedonia is a key symptom of major depressive disorder (MDD) and comprises behavioural deficits in three reward processing subtypes: reward liking, reward wanting, and reward learning. However, neuroimaging findings regarding the neural abnormalities underpinning these deficits are complex. We have conducted a systematic review to update, reframe and summarize neuroimaging findings across the three subtypes of anhedonia in MDD. Using PubMed, The Cochrane Library, PsycINFO, and Web of Science databases, we identified 59 fMRI studies comparing participants with current or remitted MDD with controls, using reward processing tasks. For reward liking and wanting, striatal hypoactivation was observed, alongside hypoactivation and hyperactivation across frontal regions. For reward learning, blunted frontostriatal sensitivity to positive feedback was observed. These findings highlight the importance of studying anhedonia not only as a clinical manifestation but also as a neurobiological mechanism underlying depressive disorder and other broader psychiatric conditions.
AB - Anhedonia is a key symptom of major depressive disorder (MDD) and comprises behavioural deficits in three reward processing subtypes: reward liking, reward wanting, and reward learning. However, neuroimaging findings regarding the neural abnormalities underpinning these deficits are complex. We have conducted a systematic review to update, reframe and summarize neuroimaging findings across the three subtypes of anhedonia in MDD. Using PubMed, The Cochrane Library, PsycINFO, and Web of Science databases, we identified 59 fMRI studies comparing participants with current or remitted MDD with controls, using reward processing tasks. For reward liking and wanting, striatal hypoactivation was observed, alongside hypoactivation and hyperactivation across frontal regions. For reward learning, blunted frontostriatal sensitivity to positive feedback was observed. These findings highlight the importance of studying anhedonia not only as a clinical manifestation but also as a neurobiological mechanism underlying depressive disorder and other broader psychiatric conditions.
KW - Anhedonia
KW - Depression
KW - fMRI
KW - Neuroimaging
KW - Reward processing
UR - http://www.scopus.com/inward/record.url?scp=85088222182&partnerID=8YFLogxK
U2 - 10.3758/s13415-020-00804-6
DO - 10.3758/s13415-020-00804-6
M3 - Review article
C2 - 32472419
AN - SCOPUS:85088222182
SN - 1530-7026
VL - 20
SP - 816
EP - 841
JO - Cognitive, Affective and Behavioral Neuroscience
JF - Cognitive, Affective and Behavioral Neuroscience
IS - 4
ER -