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Charge transport at the protein–electrode interface in the emerging field of BioMolecular Electronics

Research output: Contribution to journalReview articlepeer-review

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Charge transport at the protein–electrode interface in the emerging field of BioMolecular Electronics. / Ha, Tracy Q.; Planje, Inco J.; White, Jhanelle R.G.; Aragonès, Albert C.; Díez-Pérez, Ismael.

In: Current Opinion in Electrochemistry, Vol. 28, 100734, 08.2021.

Research output: Contribution to journalReview articlepeer-review

Harvard

Ha, TQ, Planje, IJ, White, JRG, Aragonès, AC & Díez-Pérez, I 2021, 'Charge transport at the protein–electrode interface in the emerging field of BioMolecular Electronics', Current Opinion in Electrochemistry, vol. 28, 100734. https://doi.org/10.1016/j.coelec.2021.100734

APA

Ha, T. Q., Planje, I. J., White, J. R. G., Aragonès, A. C., & Díez-Pérez, I. (2021). Charge transport at the protein–electrode interface in the emerging field of BioMolecular Electronics. Current Opinion in Electrochemistry, 28, [100734]. https://doi.org/10.1016/j.coelec.2021.100734

Vancouver

Ha TQ, Planje IJ, White JRG, Aragonès AC, Díez-Pérez I. Charge transport at the protein–electrode interface in the emerging field of BioMolecular Electronics. Current Opinion in Electrochemistry. 2021 Aug;28. 100734. https://doi.org/10.1016/j.coelec.2021.100734

Author

Ha, Tracy Q. ; Planje, Inco J. ; White, Jhanelle R.G. ; Aragonès, Albert C. ; Díez-Pérez, Ismael. / Charge transport at the protein–electrode interface in the emerging field of BioMolecular Electronics. In: Current Opinion in Electrochemistry. 2021 ; Vol. 28.

Bibtex Download

@article{fc3d9ea1956649568cfc45c4a698d469,
title = "Charge transport at the protein–electrode interface in the emerging field of BioMolecular Electronics",
abstract = "The emerging field of BioMolecular Electronics aims to unveil the charge transport characteristics of biomolecules with two primary outcomes envisioned. The first is to use nature's efficient charge transport mechanisms as an inspiration to build the next generation of hybrid bioelectronic devices towards a more sustainable, biocompatible and efficient technology. The second is to understand this ubiquitous physicochemical process in life, exploited in many fundamental biological processes such as cell signalling, respiration, photosynthesis or enzymatic catalysis, leading us to a better understanding of disease mechanisms connected to charge diffusion. Extracting electrical signatures from a protein requires optimised methods for tethering the molecules to an electrode surface, where it is advantageous to have precise electrochemical control over the energy levels of the hybrid protein–electrode interface. Here, we review recent progress towards understanding the charge transport mechanisms through protein–electrode–protein junctions, which has led to the rapid development of the new BioMolecular Electronics field. The field has brought a new vision into the molecular electronics realm, wherein complex supramolecular structures such as proteins can efficiently transport charge over long distances when placed in a hybrid bioelectronic device. Such anomalous long-range charge transport mechanisms acutely depend on specific chemical modifications of the supramolecular protein structure and on the precisely engineered protein–electrode chemical interactions. Key areas to explore in more detail are parameters such as protein stiffness (dynamics) and intrinsic electrostatic charge and how these influence the transport pathways and mechanisms in such hybrid devices.",
keywords = "Bioengineering, BioMolecular Electronics, Contacts, Coupling, Electrode surface, Electron transfer, Electron transport, Hybridisation, Protein films, Protein–electrode interface, Single-protein junctions, STM, STM-BJ",
author = "Ha, {Tracy Q.} and Planje, {Inco J.} and White, {Jhanelle R.G.} and Aragon{\`e}s, {Albert C.} and Ismael D{\'i}ez-P{\'e}rez",
note = "Funding Information: The authors thank the European Research Commission for funding under Consolidator Grant (CoG), PE5 , ERC-2017-COG . The authors also want to thank Professor Stuart Lindsay and Professor David Cahen for the many, invaluable discussions on protein junctions the authors have had over the years. Publisher Copyright: {\textcopyright} 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = aug,
doi = "10.1016/j.coelec.2021.100734",
language = "English",
volume = "28",
journal = "Current Opinion in Electrochemistry",
issn = "2451-9103",
publisher = "Elsevier BV",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Charge transport at the protein–electrode interface in the emerging field of BioMolecular Electronics

AU - Ha, Tracy Q.

AU - Planje, Inco J.

AU - White, Jhanelle R.G.

AU - Aragonès, Albert C.

AU - Díez-Pérez, Ismael

N1 - Funding Information: The authors thank the European Research Commission for funding under Consolidator Grant (CoG), PE5 , ERC-2017-COG . The authors also want to thank Professor Stuart Lindsay and Professor David Cahen for the many, invaluable discussions on protein junctions the authors have had over the years. Publisher Copyright: © 2021 Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/8

Y1 - 2021/8

N2 - The emerging field of BioMolecular Electronics aims to unveil the charge transport characteristics of biomolecules with two primary outcomes envisioned. The first is to use nature's efficient charge transport mechanisms as an inspiration to build the next generation of hybrid bioelectronic devices towards a more sustainable, biocompatible and efficient technology. The second is to understand this ubiquitous physicochemical process in life, exploited in many fundamental biological processes such as cell signalling, respiration, photosynthesis or enzymatic catalysis, leading us to a better understanding of disease mechanisms connected to charge diffusion. Extracting electrical signatures from a protein requires optimised methods for tethering the molecules to an electrode surface, where it is advantageous to have precise electrochemical control over the energy levels of the hybrid protein–electrode interface. Here, we review recent progress towards understanding the charge transport mechanisms through protein–electrode–protein junctions, which has led to the rapid development of the new BioMolecular Electronics field. The field has brought a new vision into the molecular electronics realm, wherein complex supramolecular structures such as proteins can efficiently transport charge over long distances when placed in a hybrid bioelectronic device. Such anomalous long-range charge transport mechanisms acutely depend on specific chemical modifications of the supramolecular protein structure and on the precisely engineered protein–electrode chemical interactions. Key areas to explore in more detail are parameters such as protein stiffness (dynamics) and intrinsic electrostatic charge and how these influence the transport pathways and mechanisms in such hybrid devices.

AB - The emerging field of BioMolecular Electronics aims to unveil the charge transport characteristics of biomolecules with two primary outcomes envisioned. The first is to use nature's efficient charge transport mechanisms as an inspiration to build the next generation of hybrid bioelectronic devices towards a more sustainable, biocompatible and efficient technology. The second is to understand this ubiquitous physicochemical process in life, exploited in many fundamental biological processes such as cell signalling, respiration, photosynthesis or enzymatic catalysis, leading us to a better understanding of disease mechanisms connected to charge diffusion. Extracting electrical signatures from a protein requires optimised methods for tethering the molecules to an electrode surface, where it is advantageous to have precise electrochemical control over the energy levels of the hybrid protein–electrode interface. Here, we review recent progress towards understanding the charge transport mechanisms through protein–electrode–protein junctions, which has led to the rapid development of the new BioMolecular Electronics field. The field has brought a new vision into the molecular electronics realm, wherein complex supramolecular structures such as proteins can efficiently transport charge over long distances when placed in a hybrid bioelectronic device. Such anomalous long-range charge transport mechanisms acutely depend on specific chemical modifications of the supramolecular protein structure and on the precisely engineered protein–electrode chemical interactions. Key areas to explore in more detail are parameters such as protein stiffness (dynamics) and intrinsic electrostatic charge and how these influence the transport pathways and mechanisms in such hybrid devices.

KW - Bioengineering

KW - BioMolecular Electronics

KW - Contacts

KW - Coupling

KW - Electrode surface

KW - Electron transfer

KW - Electron transport

KW - Hybridisation

KW - Protein films

KW - Protein–electrode interface

KW - Single-protein junctions

KW - STM

KW - STM-BJ

UR - http://www.scopus.com/inward/record.url?scp=85105692079&partnerID=8YFLogxK

U2 - 10.1016/j.coelec.2021.100734

DO - 10.1016/j.coelec.2021.100734

M3 - Review article

AN - SCOPUS:85105692079

VL - 28

JO - Current Opinion in Electrochemistry

JF - Current Opinion in Electrochemistry

SN - 2451-9103

M1 - 100734

ER -

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