Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

Benjamin P. Burke; Neazar Baghdadi; Alicja E. Kownacka; Shubhanchi Nigam; Gonçalo S. Clemente; Mustafa M. Al-Yassiry; Juozas Domarkas; Mark Lorch; Martin Pickles; Peter Gibbs; Raphaël Tripier; Christopher Cawthorne; Stephen J. Archibald

doi:10.1039/c5nr02753e

Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

Benjamin P. Burke, Neazar Baghdadi, Alicja E. Kownacka, Shubhanchi Nigam, Gonçalo S. Clemente, Mustafa M. Al-Yassiry, Juozas Domarkas, Mark Lorch, Martin Pickles, Peter Gibbs, Raphaël Tripier, Christopher Cawthorne, Stephen J. Archibald^*

^*Corresponding author for this work

Imaging Chemistry & Biology

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron-oxide nanorods (NRs) coated with polyethylene glycol (PEG) and/or a tetraazamacrocyclic chelator (DO3A). Studies of the coated NRs validate their composition and confirm their properties as in vivo T₂ MRI contrast agents. Radiolabelling studies with the positron emitting radioisotope gallium-68 (t_1/2 = 68 min) demonstrate that, in the presence of the silica coating, the macrocyclic chelator was not required for preparation of highly stable radiometal-NR constructs. In vivo PET-CT and MR imaging studies show the expected high liver uptake of gallium-68 radiolabelled nanorods with no significant release of gallium-68 metal ions, validating our innovation to provide a novel simple method for labelling of iron oxide NRs with a radiometal in the absence of a chelating unit that can be used for high sensitivity liver imaging.

Original language	English
Pages (from-to)	14889-14896
Number of pages	8
Journal	Nanoscale
Volume	7
Issue number	36
DOIs	https://doi.org/10.1039/c5nr02753e
Publication status	Published - 28 Sept 2015

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title = "Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions",

abstract = "The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron-oxide nanorods (NRs) coated with polyethylene glycol (PEG) and/or a tetraazamacrocyclic chelator (DO3A). Studies of the coated NRs validate their composition and confirm their properties as in vivo T2 MRI contrast agents. Radiolabelling studies with the positron emitting radioisotope gallium-68 (t1/2 = 68 min) demonstrate that, in the presence of the silica coating, the macrocyclic chelator was not required for preparation of highly stable radiometal-NR constructs. In vivo PET-CT and MR imaging studies show the expected high liver uptake of gallium-68 radiolabelled nanorods with no significant release of gallium-68 metal ions, validating our innovation to provide a novel simple method for labelling of iron oxide NRs with a radiometal in the absence of a chelating unit that can be used for high sensitivity liver imaging.",

author = "Burke, {Benjamin P.} and Neazar Baghdadi and Kownacka, {Alicja E.} and Shubhanchi Nigam and Clemente, {Gon{\c c}alo S.} and Al-Yassiry, {Mustafa M.} and Juozas Domarkas and Mark Lorch and Martin Pickles and Peter Gibbs and Rapha{\"e}l Tripier and Christopher Cawthorne and Archibald, {Stephen J.}",

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year = "2015",

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doi = "10.1039/c5nr02753e",

language = "English",

volume = "7",

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T1 - Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

AU - Burke, Benjamin P.

AU - Baghdadi, Neazar

AU - Kownacka, Alicja E.

AU - Nigam, Shubhanchi

AU - Clemente, Gonçalo S.

AU - Al-Yassiry, Mustafa M.

AU - Domarkas, Juozas

AU - Lorch, Mark

AU - Pickles, Martin

AU - Gibbs, Peter

AU - Tripier, Raphaël

AU - Cawthorne, Christopher

AU - Archibald, Stephen J.

PY - 2015/9/28

Y1 - 2015/9/28

N2 - The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron-oxide nanorods (NRs) coated with polyethylene glycol (PEG) and/or a tetraazamacrocyclic chelator (DO3A). Studies of the coated NRs validate their composition and confirm their properties as in vivo T2 MRI contrast agents. Radiolabelling studies with the positron emitting radioisotope gallium-68 (t1/2 = 68 min) demonstrate that, in the presence of the silica coating, the macrocyclic chelator was not required for preparation of highly stable radiometal-NR constructs. In vivo PET-CT and MR imaging studies show the expected high liver uptake of gallium-68 radiolabelled nanorods with no significant release of gallium-68 metal ions, validating our innovation to provide a novel simple method for labelling of iron oxide NRs with a radiometal in the absence of a chelating unit that can be used for high sensitivity liver imaging.

AB - The commercial availability of combined magnetic resonance imaging (MRI)/positron emission tomography (PET) scanners for clinical use has increased demand for easily prepared agents which offer signal or contrast in both modalities. Herein we describe a new class of silica coated iron-oxide nanorods (NRs) coated with polyethylene glycol (PEG) and/or a tetraazamacrocyclic chelator (DO3A). Studies of the coated NRs validate their composition and confirm their properties as in vivo T2 MRI contrast agents. Radiolabelling studies with the positron emitting radioisotope gallium-68 (t1/2 = 68 min) demonstrate that, in the presence of the silica coating, the macrocyclic chelator was not required for preparation of highly stable radiometal-NR constructs. In vivo PET-CT and MR imaging studies show the expected high liver uptake of gallium-68 radiolabelled nanorods with no significant release of gallium-68 metal ions, validating our innovation to provide a novel simple method for labelling of iron oxide NRs with a radiometal in the absence of a chelating unit that can be used for high sensitivity liver imaging.

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ER -

Chelator free gallium-68 radiolabelling of silica coated iron oxide nanorods via surface interactions

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