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Chemo-Enzymatic Metathesis/Aromatization Cascades for the Synthesis of Furans: Disclosing the Aromatizing Activity of Laccase/TEMPO in Oxygen-Containing Heterocycles

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)7264-7269
Number of pages6
JournalACS Catalysis
Volume9
Issue number8
DOIs
Published2 Aug 2019

King's Authors

Abstract

The unprecedented Trametes versicolor laccase/TEMPO-catalyzed aromatization of 2,5-dihydrofurans to furans is described. A variety of furan derivatives have been synthesized in moderate to high conversions (21-99%) and yields (20-76%) under mild reaction conditions. This work reveals the aromatization ability of the Trametes versicolor laccase/TEMPO system in synthesizing oxygen-containing heterocycles. Moreover, the direct synthesis of furans from aliphatic diallyl ethers through a chemo-enzymatic metathesis/aromatization cascade, which combines Grubbs-catalyzed ring-closing metathesis and laccase/TEMPO-catalyzed aromatization in the same reaction medium, has been successfully developed.

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