Child Development and Molecular Genetics: 14 Years Later

TY - JOUR

T1 - Child Development and Molecular Genetics

T2 - 14 Years Later

AU - Plomin, Robert

PY - 2013/1

Y1 - 2013/1

N2 - Fourteen years ago, the first article on molecular genetics was published in this journal: Child Development, Molecular Genetics, and What to Do With Genes Once They Are Found (R. Plomin & M. Rutter, 1998). The goal of the article was to outline what developmentalists can do with genes once they are found. These new directions for developmental research are still relevant today. The problem lies with the phrase ‘‘once they are found’’: It has been much more difficult than expected to identify genes responsible for the heritability of complex traits and common disorders, the so-called missing heritability problem. The present article considersreasons for the missing heritability problem and possible solutions.

AB - Fourteen years ago, the first article on molecular genetics was published in this journal: Child Development, Molecular Genetics, and What to Do With Genes Once They Are Found (R. Plomin & M. Rutter, 1998). The goal of the article was to outline what developmentalists can do with genes once they are found. These new directions for developmental research are still relevant today. The problem lies with the phrase ‘‘once they are found’’: It has been much more difficult than expected to identify genes responsible for the heritability of complex traits and common disorders, the so-called missing heritability problem. The present article considersreasons for the missing heritability problem and possible solutions.

U2 - 10.1111/j.1467-8624.2012.01757.x

DO - 10.1111/j.1467-8624.2012.01757.x

M3 - Article

SN - 0009-3920

VL - 84

SP - 104

EP - 120

JO - Child Development

JF - Child Development

IS - 1

ER -