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Childhood adversity and conduct disorder: A developmental pathway to violence in schizophrenia

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Childhood adversity and conduct disorder: A developmental pathway to violence in schizophrenia. / Oakley, Clare; Harris, Stephanie Therese; Fahy, Thomas; Murphy, Declan G; Picchioni, Marco.

In: Schizophrenia Research, 12.02.2016.

Research output: Contribution to journalArticle

Harvard

Oakley, C, Harris, ST, Fahy, T, Murphy, DG & Picchioni, M 2016, 'Childhood adversity and conduct disorder: A developmental pathway to violence in schizophrenia', Schizophrenia Research. https://doi.org/10.1016/j.schres.2016.01.047

APA

Oakley, C., Harris, S. T., Fahy, T., Murphy, D. G., & Picchioni, M. (2016). Childhood adversity and conduct disorder: A developmental pathway to violence in schizophrenia. Schizophrenia Research. https://doi.org/10.1016/j.schres.2016.01.047

Vancouver

Oakley C, Harris ST, Fahy T, Murphy DG, Picchioni M. Childhood adversity and conduct disorder: A developmental pathway to violence in schizophrenia. Schizophrenia Research. 2016 Feb 12. https://doi.org/10.1016/j.schres.2016.01.047

Author

Oakley, Clare ; Harris, Stephanie Therese ; Fahy, Thomas ; Murphy, Declan G ; Picchioni, Marco. / Childhood adversity and conduct disorder: A developmental pathway to violence in schizophrenia. In: Schizophrenia Research. 2016.

Bibtex Download

@article{fdd6aa06e5dd4ad5a1ed06c54bcee3e0,
title = "Childhood adversity and conduct disorder: A developmental pathway to violence in schizophrenia",
abstract = "BackgroundBoth childhood adversity and conduct disorder are over-represented among adult patients with schizophrenia and have been proposed as significant factors that may increase the risk of violence. It is not known how childhood adversity and conduct disorder might interact to contribute towards an increased risk of violence in schizophrenia. This study aimed to explore the relationships between childhood adversity, conduct disorder and violence among men with schizophrenia.Methods54 male patients with schizophrenia from a range of inpatient and outpatient mental health services were assessed for exposure to a variety of childhood adversities, conduct disorder before the age of 15 and later violent behaviour in adulthood.ResultsExposure to domestic violence during childhood was associated with an increased propensity to violence in adulthood. Symptoms of conduct disorder were associated both with cumulative exposure to childhood adversities and with later propensity to violence. The cumulative number of childhood adversities was associated with adult propensity to violence. This association was significantly attenuated by inclusion of conduct disorder in the model.ConclusionsThis is the first study to demonstrate an association between childhood exposure to domestic violence and later violent behaviour in schizophrenia. Conduct disorder may mediate the association between cumulative childhood adversities and adult propensity to violence, indicating an indirect pathway. These results indicate a complex interplay between childhood adversity, conduct disorder and later violent behaviour in schizophrenia, and suggest that there may be shared aetiological risk factors on a common developmental pathway to violence.",
author = "Clare Oakley and Harris, {Stephanie Therese} and Thomas Fahy and Murphy, {Declan G} and Marco Picchioni",
year = "2016",
month = "2",
day = "12",
doi = "10.1016/j.schres.2016.01.047",
language = "English",
journal = "Schizophrenia Research",
issn = "0920-9964",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Childhood adversity and conduct disorder: A developmental pathway to violence in schizophrenia

AU - Oakley, Clare

AU - Harris, Stephanie Therese

AU - Fahy, Thomas

AU - Murphy, Declan G

AU - Picchioni, Marco

PY - 2016/2/12

Y1 - 2016/2/12

N2 - BackgroundBoth childhood adversity and conduct disorder are over-represented among adult patients with schizophrenia and have been proposed as significant factors that may increase the risk of violence. It is not known how childhood adversity and conduct disorder might interact to contribute towards an increased risk of violence in schizophrenia. This study aimed to explore the relationships between childhood adversity, conduct disorder and violence among men with schizophrenia.Methods54 male patients with schizophrenia from a range of inpatient and outpatient mental health services were assessed for exposure to a variety of childhood adversities, conduct disorder before the age of 15 and later violent behaviour in adulthood.ResultsExposure to domestic violence during childhood was associated with an increased propensity to violence in adulthood. Symptoms of conduct disorder were associated both with cumulative exposure to childhood adversities and with later propensity to violence. The cumulative number of childhood adversities was associated with adult propensity to violence. This association was significantly attenuated by inclusion of conduct disorder in the model.ConclusionsThis is the first study to demonstrate an association between childhood exposure to domestic violence and later violent behaviour in schizophrenia. Conduct disorder may mediate the association between cumulative childhood adversities and adult propensity to violence, indicating an indirect pathway. These results indicate a complex interplay between childhood adversity, conduct disorder and later violent behaviour in schizophrenia, and suggest that there may be shared aetiological risk factors on a common developmental pathway to violence.

AB - BackgroundBoth childhood adversity and conduct disorder are over-represented among adult patients with schizophrenia and have been proposed as significant factors that may increase the risk of violence. It is not known how childhood adversity and conduct disorder might interact to contribute towards an increased risk of violence in schizophrenia. This study aimed to explore the relationships between childhood adversity, conduct disorder and violence among men with schizophrenia.Methods54 male patients with schizophrenia from a range of inpatient and outpatient mental health services were assessed for exposure to a variety of childhood adversities, conduct disorder before the age of 15 and later violent behaviour in adulthood.ResultsExposure to domestic violence during childhood was associated with an increased propensity to violence in adulthood. Symptoms of conduct disorder were associated both with cumulative exposure to childhood adversities and with later propensity to violence. The cumulative number of childhood adversities was associated with adult propensity to violence. This association was significantly attenuated by inclusion of conduct disorder in the model.ConclusionsThis is the first study to demonstrate an association between childhood exposure to domestic violence and later violent behaviour in schizophrenia. Conduct disorder may mediate the association between cumulative childhood adversities and adult propensity to violence, indicating an indirect pathway. These results indicate a complex interplay between childhood adversity, conduct disorder and later violent behaviour in schizophrenia, and suggest that there may be shared aetiological risk factors on a common developmental pathway to violence.

U2 - 10.1016/j.schres.2016.01.047

DO - 10.1016/j.schres.2016.01.047

M3 - Article

JO - Schizophrenia Research

JF - Schizophrenia Research

SN - 0920-9964

ER -

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