Childhood maltreatment, educational attainment and IQ: findings from a multicentric case-control study of first-episode psychosis (EU-GEI)

Lucia Sideli; Adriano Schimmenti; Daniele La Barbera; Caterina La Cascia; Laura Ferraro; Monica Aas; Luis Alameda; Eva Velthorst; Helen Fisher; Vincenzo Caretti; Giulia Trotta; Giada Tripoli; Diego Quattrone; Charlotte Gayer-Anderson; Fabio Seminerio; Crocettarachele Sartorio; Giovanna Marrazzo; A Lasalvia; S Tosato; Ilaria Tarricone; Domenico Berardi; Giuseppe D’Andrea; EU-GEI WP2 Group; Celso Arango; Manuel Arrojo; Miquel Bernardo; Julio Bobes; Julio Sanjuán; Jose Luis Santos; Paulo Rossi Menezes; Cristina Marta Del-Ben; Hannah E. Jongsma; Peter B Jones; James B Kirkbride; Pierre-Michel Llorca; Andrea Tortelli; Baptiste Pignon; Liewe de Haan; Jean Paul Selten; Jim van Os; Bart Pf Rutten; Marta Di Forti; Craig Morgan; Robin Murray

doi:10.1093/schbul/sbac004

Childhood maltreatment, educational attainment and IQ: findings from a multicentric case-control study of first-episode psychosis (EU-GEI)

Lucia Sideli, Adriano Schimmenti, Daniele La Barbera, Caterina La Cascia, Laura Ferraro, Monica Aas, Luis Alameda, Eva Velthorst, Helen Fisher, Vincenzo Caretti, Giulia Trotta, Giada Tripoli, Diego Quattrone, Charlotte Gayer-Anderson, Fabio Seminerio, Crocettarachele Sartorio, Giovanna Marrazzo, A Lasalvia, S Tosato, Ilaria TarriconeDomenico Berardi, Giuseppe D’Andrea, EU-GEI WP2 Group, Celso Arango, Manuel Arrojo, Miquel Bernardo, Julio Bobes, Julio Sanjuán, Jose Luis Santos, Paulo Rossi Menezes, Cristina Marta Del-Ben, Hannah E. Jongsma, Peter B Jones, James B Kirkbride, Pierre-Michel Llorca, Andrea Tortelli, Baptiste Pignon, Liewe de Haan, Jean Paul Selten, Jim van Os, Bart Pf Rutten, Marta Di Forti, Craig Morgan, Robin Murray

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Abstract

Background and hypothesis: Evidence suggests that childhood maltreatment (i.e., childhood abuse and childhood neglect) affects educational attainment and cognition. However, the association between childhood maltreatment and Intelligence Quotient (IQ) seems stronger among controls compared to people with psychosis. We hypothesised that: the association between childhood maltreatment and poor cognition would be stronger among community controls than among people with first-episode of psychosis (FEP); compared to abuse, neglect would show stronger associations with educational attainment and cognition; the association between childhood maltreatment and IQ would be partially accounted for by other risk factors; and the association between childhood maltreatment, educational attainment and IQ would be stronger among patients with affective psychoses compared to those with non-affective psychoses.

Study Design: 829 patients with FEP and 1283 community controls from 16 EU-GEI sites were assessed for child maltreatment, education attainment, and IQ.

Study Results: In both the FEP and control group, childhood maltreatment was associated with lower educational attainment. The association between childhood maltreatment and lower IQ was robust to adjustment for confounders only among controls. Whereas childhood neglect was consistently associated with lower attainment and IQ in both groups, childhood abuse was associated with IQ only in controls. Among both patients with affective and non-affective psychoses, negative associations between childhood maltreatment and educational attainment were observed, but the crude association with IQ was only evident in affective psychoses.

Conclusions: Our findings underscore the role of childhood maltreatment in shaping academic outcomes and cognition of people with FEP as well as controls.

Original language	English
Pages (from-to)	575-589
Number of pages	15
Journal	Schizophrenia Bulletin
Volume	48
Issue number	3
Early online date	9 Feb 2022
DOIs	https://doi.org/10.1093/schbul/sbac004
Publication status	Published - 1 May 2022

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Sideli, L., Schimmenti, A., La Barbera, D., La Cascia, C., Ferraro, L., Aas, M., Alameda, L., Velthorst, E., Fisher, H., Caretti, V., Trotta, G., Tripoli, G., Quattrone, D., Gayer-Anderson, C., Seminerio, F., Sartorio, C., Marrazzo, G., Lasalvia, A., Tosato, S., ... Murray, R. (2022). Childhood maltreatment, educational attainment and IQ: findings from a multicentric case-control study of first-episode psychosis (EU-GEI). Schizophrenia Bulletin, 48(3), 575-589. https://doi.org/10.1093/schbul/sbac004

@article{f11f7010840742ecb4267e561c13a07f,

title = "Childhood maltreatment, educational attainment and IQ: findings from a multicentric case-control study of first-episode psychosis (EU-GEI)",

abstract = "Background and hypothesis: Evidence suggests that childhood maltreatment (i.e., childhood abuse and childhood neglect) affects educational attainment and cognition. However, the association between childhood maltreatment and Intelligence Quotient (IQ) seems stronger among controls compared to people with psychosis. We hypothesised that: the association between childhood maltreatment and poor cognition would be stronger among community controls than among people with first-episode of psychosis (FEP); compared to abuse, neglect would show stronger associations with educational attainment and cognition; the association between childhood maltreatment and IQ would be partially accounted for by other risk factors; and the association between childhood maltreatment, educational attainment and IQ would be stronger among patients with affective psychoses compared to those with non-affective psychoses.Study Design: 829 patients with FEP and 1283 community controls from 16 EU-GEI sites were assessed for child maltreatment, education attainment, and IQ. Study Results: In both the FEP and control group, childhood maltreatment was associated with lower educational attainment. The association between childhood maltreatment and lower IQ was robust to adjustment for confounders only among controls. Whereas childhood neglect was consistently associated with lower attainment and IQ in both groups, childhood abuse was associated with IQ only in controls. Among both patients with affective and non-affective psychoses, negative associations between childhood maltreatment and educational attainment were observed, but the crude association with IQ was only evident in affective psychoses.Conclusions: Our findings underscore the role of childhood maltreatment in shaping academic outcomes and cognition of people with FEP as well as controls. ",

author = "Lucia Sideli and Adriano Schimmenti and {La Barbera}, Daniele and {La Cascia}, Caterina and Laura Ferraro and Monica Aas and Luis Alameda and Eva Velthorst and Helen Fisher and Vincenzo Caretti and Giulia Trotta and Giada Tripoli and Diego Quattrone and Charlotte Gayer-Anderson and Fabio Seminerio and Crocettarachele Sartorio and Giovanna Marrazzo and A Lasalvia and S Tosato and Ilaria Tarricone and Domenico Berardi and Giuseppe D{\textquoteright}Andrea and {EU-GEI WP2 Group} and Celso Arango and Manuel Arrojo and Miquel Bernardo and Julio Bobes and Julio Sanju{\'a}n and Santos, {Jose Luis} and Menezes, {Paulo Rossi} and Del-Ben, {Cristina Marta} and Jongsma, {Hannah E.} and Jones, {Peter B} and Kirkbride, {James B} and Pierre-Michel Llorca and Andrea Tortelli and Baptiste Pignon and {de Haan}, Liewe and Selten, {Jean Paul} and {van Os}, Jim and Rutten, {Bart Pf} and {Di Forti}, Marta and Craig Morgan and Robin Murray",

year = "2022",

month = may,

day = "1",

doi = "10.1093/schbul/sbac004",

language = "English",

volume = "48",

pages = "575--589",

journal = "Schizophrenia Bulletin",

issn = "0586-7614",

publisher = "Oxford University Press",

number = "3",

}

Sideli, L, Schimmenti, A, La Barbera, D, La Cascia, C, Ferraro, L, Aas, M , Alameda, L, Velthorst, E, Fisher, H, Caretti, V, Trotta, G, Tripoli, G, Quattrone, D , Gayer-Anderson, C, Seminerio, F, Sartorio, C, Marrazzo, G, Lasalvia, A, Tosato, S, Tarricone, I, Berardi, D, D’Andrea, G, EU-GEI WP2 Group, Arango, C, Arrojo, M, Bernardo, M, Bobes, J, Sanjuán, J, Santos, JL, Menezes, PR, Del-Ben, CM, Jongsma, HE, Jones, PB, Kirkbride, JB, Llorca, P-M, Tortelli, A, Pignon, B, de Haan, L, Selten, JP, van Os, J, Rutten, BP, Di Forti, M , Morgan, C & Murray, R 2022, 'Childhood maltreatment, educational attainment and IQ: findings from a multicentric case-control study of first-episode psychosis (EU-GEI)', Schizophrenia Bulletin, vol. 48, no. 3, pp. 575-589. https://doi.org/10.1093/schbul/sbac004

TY - JOUR

T1 - Childhood maltreatment, educational attainment and IQ: findings from a multicentric case-control study of first-episode psychosis (EU-GEI)

AU - Sideli, Lucia

AU - Schimmenti, Adriano

AU - La Barbera, Daniele

AU - La Cascia, Caterina

AU - Ferraro, Laura

AU - Aas, Monica

AU - Alameda, Luis

AU - Velthorst, Eva

AU - Fisher, Helen

AU - Caretti, Vincenzo

AU - Trotta, Giulia

AU - Tripoli, Giada

AU - Quattrone, Diego

AU - Gayer-Anderson, Charlotte

AU - Seminerio, Fabio

AU - Sartorio, Crocettarachele

AU - Marrazzo, Giovanna

AU - Lasalvia, A

AU - Tosato, S

AU - Tarricone, Ilaria

AU - Berardi, Domenico

AU - D’Andrea, Giuseppe

AU - EU-GEI WP2 Group

AU - Arango, Celso

AU - Arrojo, Manuel

AU - Bernardo, Miquel

AU - Bobes, Julio

AU - Sanjuán, Julio

AU - Santos, Jose Luis

AU - Menezes, Paulo Rossi

AU - Del-Ben, Cristina Marta

AU - Jongsma, Hannah E.

AU - Jones, Peter B

AU - Kirkbride, James B

AU - Llorca, Pierre-Michel

AU - Tortelli, Andrea

AU - Pignon, Baptiste

AU - de Haan, Liewe

AU - Selten, Jean Paul

AU - van Os, Jim

AU - Rutten, Bart Pf

AU - Di Forti, Marta

AU - Morgan, Craig

AU - Murray, Robin

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Background and hypothesis: Evidence suggests that childhood maltreatment (i.e., childhood abuse and childhood neglect) affects educational attainment and cognition. However, the association between childhood maltreatment and Intelligence Quotient (IQ) seems stronger among controls compared to people with psychosis. We hypothesised that: the association between childhood maltreatment and poor cognition would be stronger among community controls than among people with first-episode of psychosis (FEP); compared to abuse, neglect would show stronger associations with educational attainment and cognition; the association between childhood maltreatment and IQ would be partially accounted for by other risk factors; and the association between childhood maltreatment, educational attainment and IQ would be stronger among patients with affective psychoses compared to those with non-affective psychoses.Study Design: 829 patients with FEP and 1283 community controls from 16 EU-GEI sites were assessed for child maltreatment, education attainment, and IQ. Study Results: In both the FEP and control group, childhood maltreatment was associated with lower educational attainment. The association between childhood maltreatment and lower IQ was robust to adjustment for confounders only among controls. Whereas childhood neglect was consistently associated with lower attainment and IQ in both groups, childhood abuse was associated with IQ only in controls. Among both patients with affective and non-affective psychoses, negative associations between childhood maltreatment and educational attainment were observed, but the crude association with IQ was only evident in affective psychoses.Conclusions: Our findings underscore the role of childhood maltreatment in shaping academic outcomes and cognition of people with FEP as well as controls.

AB - Background and hypothesis: Evidence suggests that childhood maltreatment (i.e., childhood abuse and childhood neglect) affects educational attainment and cognition. However, the association between childhood maltreatment and Intelligence Quotient (IQ) seems stronger among controls compared to people with psychosis. We hypothesised that: the association between childhood maltreatment and poor cognition would be stronger among community controls than among people with first-episode of psychosis (FEP); compared to abuse, neglect would show stronger associations with educational attainment and cognition; the association between childhood maltreatment and IQ would be partially accounted for by other risk factors; and the association between childhood maltreatment, educational attainment and IQ would be stronger among patients with affective psychoses compared to those with non-affective psychoses.Study Design: 829 patients with FEP and 1283 community controls from 16 EU-GEI sites were assessed for child maltreatment, education attainment, and IQ. Study Results: In both the FEP and control group, childhood maltreatment was associated with lower educational attainment. The association between childhood maltreatment and lower IQ was robust to adjustment for confounders only among controls. Whereas childhood neglect was consistently associated with lower attainment and IQ in both groups, childhood abuse was associated with IQ only in controls. Among both patients with affective and non-affective psychoses, negative associations between childhood maltreatment and educational attainment were observed, but the crude association with IQ was only evident in affective psychoses.Conclusions: Our findings underscore the role of childhood maltreatment in shaping academic outcomes and cognition of people with FEP as well as controls.

UR - http://www.scopus.com/inward/record.url?scp=85133129777&partnerID=8YFLogxK

U2 - 10.1093/schbul/sbac004

DO - 10.1093/schbul/sbac004

M3 - Article

SN - 0586-7614

VL - 48

SP - 575

EP - 589

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

IS - 3

ER -

Childhood maltreatment, educational attainment and IQ: findings from a multicentric case-control study of first-episode psychosis (EU-GEI)

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