Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses

Monica Aas; Ingrid Dieset; Sigrun Hope; Eva Hoseth; Ragni Mørch; Elina Reponen; Nils Eiel Steen; Jannicke Fjæra Laskemoen; Thor Ueland; Pål Aukrust; Ingrid Agartz; Ole A. Andreassen; Ingrid Melle

doi:10.1016/j.bbi.2017.06.005

Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses

Monica Aas^*, Ingrid Dieset, Sigrun Hope, Eva Hoseth, Ragni Mørch, Elina Reponen, Nils Eiel Steen, Jannicke Fjæra Laskemoen, Thor Ueland, Pål Aukrust, Ingrid Agartz, Ole A. Andreassen, Ingrid Melle

^*Corresponding author for this work

Social Genetic & Developmental Psychiatry

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

Background Several studies have described an association between childhood maltreatment and inflammatory markers in the psychotic disorders (schizophrenia [SZ] and bipolar disorder [BD]). Previous studies have been relatively small (<50 participants), and the severity of abuse and the putative influence of body mass index (BMI) have not been properly investigated. Methods The combined effects of childhood abuse severity and clinical diagnosis on inflammatory markers were investigated in a large sample (n = 483) of patients with a disorder on the psychosis spectrum and in healthy controls (HCs). Plasma levels of inflammatory markers (high-sensitivity C-reactive protein [hs-CRP], soluble tumor necrosis factor receptor type 1 [TNFR-R1], glycoprotein 130 [gp130]) were analyzed, and BMI and data on childhood trauma events, on the basis of the Childhood Trauma Questionnaire (CTQ), were obtained from all participants. Results Patients had increased levels of hs-CRP (P < 0.001, Cohens d = 0.4), lower levels of gp130 (P < 0.001, Cohens d = 0.5), higher BMI (P < 0.001, Cohens d = 0.5) and reported more childhood maltreatment experiences (P < 0.001, Cohens d = 1.2) than the HC group. The severity of childhood abuse (up to three types of abuse: sexual abuse, physical abuse, and emotional abuse) was associated with elevated BMI (f = 8.46, P < 0.001, Cohen's d = 0.5) and hs-CRP (f = 5.47, P = 0.001, Cohen's d = 0.3). Combined effects of patient status and severity of childhood abuse were found for elevated hs-CRP (f = 4.76, P < 0.001, Cohen's d = 0.4). Differences among the groups disappeared when BMI was added to the model. Discussion Trauma-altered immune activation via elevated hs-CRP in patients with SZ and BD may be mediated by higher BMI; however, the direction of this association needs further clarification.

Original language	English
Pages (from-to)	342-349
Number of pages	8
Journal	Brain, Behavior, and Immunity
Volume	65
DOIs	https://doi.org/10.1016/j.bbi.2017.06.005
Publication status	Published - Oct 2017

Keywords

Bipolar disorders
BMI
Childhood trauma
Inflammation
Schizophrenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbi.2017.06.005

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Aas, M., Dieset, I., Hope, S., Hoseth, E., Mørch, R., Reponen, E., Steen, N. E., Laskemoen, J. F., Ueland, T., Aukrust, P., Agartz, I., Andreassen, O. A., & Melle, I. (2017). Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses. Brain, Behavior, and Immunity, 65, 342-349. https://doi.org/10.1016/j.bbi.2017.06.005

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title = "Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses",

abstract = "Background Several studies have described an association between childhood maltreatment and inflammatory markers in the psychotic disorders (schizophrenia [SZ] and bipolar disorder [BD]). Previous studies have been relatively small (<50 participants), and the severity of abuse and the putative influence of body mass index (BMI) have not been properly investigated. Methods The combined effects of childhood abuse severity and clinical diagnosis on inflammatory markers were investigated in a large sample (n = 483) of patients with a disorder on the psychosis spectrum and in healthy controls (HCs). Plasma levels of inflammatory markers (high-sensitivity C-reactive protein [hs-CRP], soluble tumor necrosis factor receptor type 1 [TNFR-R1], glycoprotein 130 [gp130]) were analyzed, and BMI and data on childhood trauma events, on the basis of the Childhood Trauma Questionnaire (CTQ), were obtained from all participants. Results Patients had increased levels of hs-CRP (P < 0.001, Cohens d = 0.4), lower levels of gp130 (P < 0.001, Cohens d = 0.5), higher BMI (P < 0.001, Cohens d = 0.5) and reported more childhood maltreatment experiences (P < 0.001, Cohens d = 1.2) than the HC group. The severity of childhood abuse (up to three types of abuse: sexual abuse, physical abuse, and emotional abuse) was associated with elevated BMI (f = 8.46, P < 0.001, Cohen's d = 0.5) and hs-CRP (f = 5.47, P = 0.001, Cohen's d = 0.3). Combined effects of patient status and severity of childhood abuse were found for elevated hs-CRP (f = 4.76, P < 0.001, Cohen's d = 0.4). Differences among the groups disappeared when BMI was added to the model. Discussion Trauma-altered immune activation via elevated hs-CRP in patients with SZ and BD may be mediated by higher BMI; however, the direction of this association needs further clarification.",

keywords = "Bipolar disorders, BMI, Childhood trauma, Inflammation, Schizophrenia",

author = "Monica Aas and Ingrid Dieset and Sigrun Hope and Eva Hoseth and Ragni M{\o}rch and Elina Reponen and Steen, {Nils Eiel} and Laskemoen, {Jannicke Fj{\ae}ra} and Thor Ueland and P{\aa}l Aukrust and Ingrid Agartz and Andreassen, {Ole A.} and Ingrid Melle",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

month = oct,

doi = "10.1016/j.bbi.2017.06.005",

language = "English",

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Aas, M, Dieset, I, Hope, S, Hoseth, E, Mørch, R, Reponen, E, Steen, NE, Laskemoen, JF, Ueland, T, Aukrust, P, Agartz, I, Andreassen, OA & Melle, I 2017, 'Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses', Brain, Behavior, and Immunity, vol. 65, pp. 342-349. https://doi.org/10.1016/j.bbi.2017.06.005

TY - JOUR

T1 - Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses

AU - Aas, Monica

AU - Dieset, Ingrid

AU - Hope, Sigrun

AU - Hoseth, Eva

AU - Mørch, Ragni

AU - Reponen, Elina

AU - Steen, Nils Eiel

AU - Laskemoen, Jannicke Fjæra

AU - Ueland, Thor

AU - Aukrust, Pål

AU - Agartz, Ingrid

AU - Andreassen, Ole A.

AU - Melle, Ingrid

PY - 2017/10

Y1 - 2017/10

N2 - Background Several studies have described an association between childhood maltreatment and inflammatory markers in the psychotic disorders (schizophrenia [SZ] and bipolar disorder [BD]). Previous studies have been relatively small (<50 participants), and the severity of abuse and the putative influence of body mass index (BMI) have not been properly investigated. Methods The combined effects of childhood abuse severity and clinical diagnosis on inflammatory markers were investigated in a large sample (n = 483) of patients with a disorder on the psychosis spectrum and in healthy controls (HCs). Plasma levels of inflammatory markers (high-sensitivity C-reactive protein [hs-CRP], soluble tumor necrosis factor receptor type 1 [TNFR-R1], glycoprotein 130 [gp130]) were analyzed, and BMI and data on childhood trauma events, on the basis of the Childhood Trauma Questionnaire (CTQ), were obtained from all participants. Results Patients had increased levels of hs-CRP (P < 0.001, Cohens d = 0.4), lower levels of gp130 (P < 0.001, Cohens d = 0.5), higher BMI (P < 0.001, Cohens d = 0.5) and reported more childhood maltreatment experiences (P < 0.001, Cohens d = 1.2) than the HC group. The severity of childhood abuse (up to three types of abuse: sexual abuse, physical abuse, and emotional abuse) was associated with elevated BMI (f = 8.46, P < 0.001, Cohen's d = 0.5) and hs-CRP (f = 5.47, P = 0.001, Cohen's d = 0.3). Combined effects of patient status and severity of childhood abuse were found for elevated hs-CRP (f = 4.76, P < 0.001, Cohen's d = 0.4). Differences among the groups disappeared when BMI was added to the model. Discussion Trauma-altered immune activation via elevated hs-CRP in patients with SZ and BD may be mediated by higher BMI; however, the direction of this association needs further clarification.

AB - Background Several studies have described an association between childhood maltreatment and inflammatory markers in the psychotic disorders (schizophrenia [SZ] and bipolar disorder [BD]). Previous studies have been relatively small (<50 participants), and the severity of abuse and the putative influence of body mass index (BMI) have not been properly investigated. Methods The combined effects of childhood abuse severity and clinical diagnosis on inflammatory markers were investigated in a large sample (n = 483) of patients with a disorder on the psychosis spectrum and in healthy controls (HCs). Plasma levels of inflammatory markers (high-sensitivity C-reactive protein [hs-CRP], soluble tumor necrosis factor receptor type 1 [TNFR-R1], glycoprotein 130 [gp130]) were analyzed, and BMI and data on childhood trauma events, on the basis of the Childhood Trauma Questionnaire (CTQ), were obtained from all participants. Results Patients had increased levels of hs-CRP (P < 0.001, Cohens d = 0.4), lower levels of gp130 (P < 0.001, Cohens d = 0.5), higher BMI (P < 0.001, Cohens d = 0.5) and reported more childhood maltreatment experiences (P < 0.001, Cohens d = 1.2) than the HC group. The severity of childhood abuse (up to three types of abuse: sexual abuse, physical abuse, and emotional abuse) was associated with elevated BMI (f = 8.46, P < 0.001, Cohen's d = 0.5) and hs-CRP (f = 5.47, P = 0.001, Cohen's d = 0.3). Combined effects of patient status and severity of childhood abuse were found for elevated hs-CRP (f = 4.76, P < 0.001, Cohen's d = 0.4). Differences among the groups disappeared when BMI was added to the model. Discussion Trauma-altered immune activation via elevated hs-CRP in patients with SZ and BD may be mediated by higher BMI; however, the direction of this association needs further clarification.

KW - Bipolar disorders

KW - BMI

KW - Childhood trauma

KW - Inflammation

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=85020930235&partnerID=8YFLogxK

U2 - 10.1016/j.bbi.2017.06.005

DO - 10.1016/j.bbi.2017.06.005

M3 - Article

C2 - 28619247

AN - SCOPUS:85020930235

SN - 0889-1591

VL - 65

SP - 342

EP - 349

JO - Brain, Behavior, and Immunity

JF - Brain, Behavior, and Immunity

ER -

Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses

Abstract

Keywords

UN SDGs

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